, Volume 37, Issue 3, pp 966–977 | Cite as

Cyane-carvone, a Synthetic Derivative of Carvone, Inhibits Inflammatory Response by Reducing Cytokine Production and Oxidative Stress and Shows Antinociceptive Effect in Mice

  • Thiago Henrique Costa Marques
  • Maria Leonildes Boavista Gomes Castelo Branco Marques
  • Jand-Venes R. Medeiros
  • Renan  Oliveira Silva
  • André Luiz dos Reis Barbosa
  • Tamires Cardoso Lima
  • Damião Pergentino de Sousa
  • Rivelilson Mendes de Freitas


Cyane-carvone (CC) was studied to elucidate its anti-inflammatory, antinociceptive, and antioxidant effects in Mus musculus. Anti-inflammatory (bradykinin, histamine, prostaglandin E2, serotonin, and carrageenan) and antinociceptive (acetic acid and formalin) models were utilized. Myeloperoxidase activity, interleukin (IL)-1β, tumor necrosis factor alpha (TNF-α), and glutathione (GSH) levels were evaluated. Analysis of variance followed by Student-Newman-Keuls’ test was done. Results were compared with control groups (significantly when p < 0.05). In bradykinin, histamine, prostaglandin E2, and serotonin tests, 75 mg/kg CC decreased significantly paw edema (t = 30, 60, 90, and/or 120 min). In carrageenan test, 50 and 75 mg/kg CC (t = 3 h and t = 4 h) and 25 mg/kg CC (t = 4 h) decreased significantly paw edema. CC (75 mg/kg) inhibited significantly mieloperoxidase activity and decreased IL-1β and TNF-α, and all doses increased GSH levels. CC (75 mg/kg) decreased significantly the number of contortions of animals and time of licking (phase 2). CC showed anti-inflammatory, antinociceptive, and antioxidant effects in mice.


anti-inflammatory antinociceptive cyane-carvone mice 



This work was funded by the National Council for Scientific and Technological Development (CNPq) and Research Supporting Foundation of State of Piauí (FAPEPI/Brazil).


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Thiago Henrique Costa Marques
    • 1
  • Maria Leonildes Boavista Gomes Castelo Branco Marques
    • 1
  • Jand-Venes R. Medeiros
    • 2
  • Renan  Oliveira Silva
    • 2
  • André Luiz dos Reis Barbosa
    • 2
  • Tamires Cardoso Lima
    • 3
  • Damião Pergentino de Sousa
    • 4
  • Rivelilson Mendes de Freitas
    • 1
  1. 1.Laboratório de Pesquisa em Neuroquímica Experimental, Curso de FarmáciaUniversidade Federal do PiauíTeresinaBrazil
  2. 2.Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC)Federal University of Piauí (UFPI)ParnaíbaBrazil
  3. 3.Post-Graduate Program in Pharmaceutics SciencesFederal University of SergipeSão CristóvãoBrazil
  4. 4.Department of Pharmaceutical ScienceFederal University of ParaibaJoão PessoaBrazil

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