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Inflammation

, Volume 36, Issue 6, pp 1218–1224 | Cite as

IL-10RB rs2834167 (A/G) Polymorphism Is Associated with the Susceptibility to Systemic Lupus Erythematosus: Evidence from a Study in Chinese Han Population

  • Hui Peng
  • Cai-Yun Liu
  • Mo Zhou
  • Peng-Fei Wen
  • Min Zhang
  • Li-Juan Qiu
  • Jing Ni
  • Yan Liang
  • Hai-Feng Pan
  • Dong-Qing Ye
Article

Abstract

Interleukin-10 (IL-10) is a pleiotropic cytokine and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Unlike IL-10 protein, few studies have focused on the potential association between IL-10 receptor (IL-10R) and SLE. The purpose of this study was to examine the association of a single nucleotide polymorphism, rs2834167 (A/G), in IL-10R2 gene (IL-10RB) with SLE in a Chinese Han population. A total of 667 patients with SLE and 676 healthy controls were enrolled in the present study. IL-10RB rs2834167 (A/G) polymorphism was specified from genomic DNA using TaqMan genotyping assay on a 7300 real-time reverse transcription polymerase chain reaction system. We found that the frequency of A allele for rs2834167 in patients (44.53 %) was significantly higher than in controls (40.16 %) (χ 2 = 5.24, P = 0.022). Allele A was associated with a 1.196-fold (95 % confidence interval (CI), 1.026–1.394) greater risk for the occurrence of SLE compared with the G allele. And both genotypes AG and AA were associated with the susceptibility to SLE as compared with the GG genotype (AG versus GG, odds ratio (OR) = 1.332; 95 %CI, 1.047–1.696; AA versus GG, OR = 1.373; 95 %CI, 1.004–1.878). We also found a statistical significance in the dominant model (AA + AG versus GG, OR = 1.343; 95 %CI, 1.070–1.687). However, no significant evidence for the association of IL-10RB rs2834167 (A/G) polymorphism with any clinical manifestations was detected. Our observations indicate that IL-10RB rs2834167 (A/G) polymorphism may be a potential biomarker for susceptibility to SLE.

KEY WORDS

systemic lupus erythematosus interleukin-10 receptor 2 single nucleotide polymorphism susceptibility 

Notes

ACKNOWLEDGMENTS

This work was supported by the National Natural Science Foundation (30830089, 81172764, 81102192) and the Anhui Provincial Natural Science Foundation (11040606 M183).

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hui Peng
    • 1
    • 2
    • 3
  • Cai-Yun Liu
    • 4
  • Mo Zhou
    • 1
    • 2
  • Peng-Fei Wen
    • 1
    • 2
  • Min Zhang
    • 1
    • 2
  • Li-Juan Qiu
    • 1
    • 2
  • Jing Ni
    • 1
    • 2
  • Yan Liang
    • 1
    • 2
  • Hai-Feng Pan
    • 1
    • 2
  • Dong-Qing Ye
    • 1
    • 2
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiPeople’s Republic of China
  2. 2.Anhui Provincial Laboratory of Population Health & Major Disease Screening and DiagnosisAnhui Medical UniversityHefeiPeople’s Republic of China
  3. 3.Department of Hospital Infection Management, Yijishan HospitalWannan Medical CollegeWuhuPeople’s Republic of China
  4. 4.Department of Human Resourcesthe Second People’s Hospital of Wuhu CityWuhuPeople’s Republic of China

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