, Volume 36, Issue 4, pp 878–887 | Cite as

Plasma Concentration of Soluble Intercellular Adhesion Molecule-1 (sICAM-1) is Elevated in Type 2 Diabetic Patients, and sICAM-1 Synthesis is Associated with Leptin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway

  • Jin Joo Cha
  • Young Youl Hyun
  • Yi Hwa Jee
  • Mi Jin Lee
  • Kum Hyun Han
  • Young Sun Kang
  • Sang Youb Han
  • Dae Ryong Cha


The intercellular adhesion molecule-1 (ICAM-1) and leptin are important inflammatory biomarkers. We investigated whether plasma-soluble ICAM-1 levels were related to the diabetic nephropathy and systemic inflammation. One hundred forty-seven type 2 diabetic patients and 46 healthy control subjects were studied. Plasma sICAM-1 concentrations were significantly higher in the diabetic groups than controls and increased significantly as diabetic nephropathy advanced. Plasma sICAM-1 levels were positively correlated with body mass index, fasting and postprandial blood glucose, urinary albumin excretion, and negatively correlated with creatinine clearance. Multiple regression analysis showed that plasma leptin levels were associated with a significant increase in plasma sICAM-1 levels. In cultured HUVECs, leptin increased ICAM-1 production in a dose-dependent manner, and this stimulating effect of leptin on ICAM-1 expression was reversed by MEK inhibitor, PD98059. Overall, these findings suggest that activation of leptin synthesis in a diabetic environment promotes ICAM-1 activation via mitogen-activated protein kinase pathway in type 2 diabetic patients.

Key words

diabetic nephropathy HUVECs ICAM-1 leptin type 2 diabetic patients 



This work was supported by the Brain Korea 21 project in 2012.

Conflict of interest

The authors state that there is no conflict of interest for this study.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jin Joo Cha
    • 1
  • Young Youl Hyun
    • 2
  • Yi Hwa Jee
    • 1
  • Mi Jin Lee
    • 1
  • Kum Hyun Han
    • 3
  • Young Sun Kang
    • 1
  • Sang Youb Han
    • 3
  • Dae Ryong Cha
    • 1
  1. 1.Department of Internal MedicineKorea University Ansan HospitalAnsan CitySouth Korea
  2. 2.Department of Internal MedicineSungkyunkwan University Kangbuk Samsung HospitalSeoulSouth Korea
  3. 3.Department of Internal MedicineInje University Ilsan-Paik HospitalIlsanSouth Korea

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