, Volume 36, Issue 3, pp 625–632 | Cite as

Effects of Chronic Exercise Training on Inflammatory Markers in Australian Overweight and Obese Individuals in a Randomized Controlled Trial

  • Suleen S. Ho
  • Satvinder S. Dhaliwal
  • Andrew P. Hills
  • Sebely Pal


Physical activity has been shown to lower levels of inflammatory markers. However, results are inconsistent, indicating different modes of exercise may have different effects on inflammatory cytokines. We aimed to investigate the effects of 12 weeks of moderate-intensity aerobic, resistance, or combination exercise on TNF-α and IL-6 compared to no exercise in overweight and obese individuals. TNF-α levels were significantly decreased at week 12 compared to baseline by 20.8 % in the Aerobic group (p = 0.011), 26.9 % in the Resistance group (p = 0.0001), and 32.6 % in the Combination group (p = 0.003). Levels of TNF-α were significantly lower in the Combination compared to the Control group after 12 weeks of exercise training (−22.6 %, p = 0.025) when adjusting for baseline levels. Twelve weeks of moderate-intensity aerobic, resistance, but mainly combination exercise training decreased TNF-α in overweight and obese individuals compared to no exercise. Therefore, combination exercise training may be physiologically relevant in decreasing the risk of developing chronic diseases.


obesity overweight tumor necrosis factor-α interleukin-6 exercise training 


Acknowledgments and Contributions

SH coordinated the trial, conducted data collection, and had input into the manuscript. APH had input into the writing of the manuscript and SSD provided statistical oversight. SSD developed the statistical analysis protocol and performed statistical analysis in conjunction with SH. SP conceived and designed the study, supervised the study and the statistical analysis, and mentored SH. The authors declare that they have no conflicts of interest. This trial was partially funded by Curtin DRG grant and ATN Centre for Metabolic Fitness.


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Suleen S. Ho
    • 1
  • Satvinder S. Dhaliwal
    • 1
  • Andrew P. Hills
    • 2
  • Sebely Pal
    • 1
  1. 1.School of Public Health, Curtin Health Innovation Research InstituteCurtin UniversityPerthAustralia
  2. 2.Mater Mother’s Hospital, Mater Medical Research Institute, Conjoint Appointment with Griffith Health InstituteGriffith UniversitySouth BrisbaneAustralia

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