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Inflammation

, Volume 36, Issue 1, pp 121–130 | Cite as

Possible Involvement of Toll-Like Receptors in the Pathogenesis of Myasthenia Gravis

  • Yu-Zhong Wang
  • Mei Yan
  • Fa-Fa Tian
  • Jun-Mei Zhang
  • Qun Liu
  • Huan Yang
  • Wen-Bin Zhou
  • Jing Li
Article

Abstract

Toll-like receptors (TLRs), the innate immunity components, have been demonstrated to participate in multiple autoimmune diseases. However, our knowledge of the roles of TLRs in myasthenia gravis (MG) is still scarce. In this study, we detected the mRNA expression of TLR1 to TLR10 in peripheral blood mononuclear cells (PBMCs) of MG patients and the healthy controls by quantitative real-time polymerase transcription chain reaction. Our data demonstrate that aberrant expressions of TLRs exist in the PBMCs of MG patients and of the total, expression level of TLR9 mRNA has significantly positive relation with the clinical severity of MG, which suggests that TLRs may be involved in the pathogenesis of MG.

KEY WORDS

myasthenia gravis Toll-like receptors innate immunity 

Notes

Acknowledgment

This work was supported by the National Natural Science Foundation of China (30971033).

Conflict of Interest

The authors declare no competing financial interests.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Yu-Zhong Wang
    • 1
    • 2
  • Mei Yan
    • 1
  • Fa-Fa Tian
    • 1
  • Jun-Mei Zhang
    • 1
  • Qun Liu
    • 1
  • Huan Yang
    • 1
  • Wen-Bin Zhou
    • 1
  • Jing Li
    • 1
  1. 1.Department of Neurology, Xiangya HospitalCentral South UniversityChangshaPeople’s Republic of China
  2. 2.Department of NeurologyAffiliated Hospital of Jining Medical CollegeJiningPeople’s Republic of China

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