, Volume 35, Issue 6, pp 1872–1879 | Cite as

Anti-Inflammatory Effect of 3,4-Oxo-isopropylidene-shikimic Acid on Acetic Acid-Induced Colitis in Rats

  • Jianfeng Xing
  • Jinyao Sun
  • Haisheng You
  • Jun Lv
  • Jianning Sun
  • Yalin Dong


The present work was done to investigate the possible effects of 3,4-oxo-isopropylidene-shikimic acid (ISA) on acetic acid (AA)-induced colitis in rats. Colitis was induced by intracolonic injection of 6 % AA. Several parameters, including macroscopic score and biochemical parameters, were determined to assess the degree of protection. Biochemical parameters such as myeloperoxidase (MPO) activity, malondialdehyde (MDA) and nitric oxide (NO) levels, and superoxide dismutase (SOD) and inducible NO synthase (NOS) activities were measured following standard assay procedures. The study showed that treatment of rats for 6 days with ISA (100 and 200 mg/kg) was able to give complete protection against AA-induced colitis. Moreover, biochemical changes were reversed and brought toward control. These results suggest a beneficial effect of ISA against experimental colitis and the possible mechanism of the protective effects may be partly due to an antioxidant action.


3,4-oxo-isopropylidene-shikimic acid ulcerative colitis acetic acid antioxidation 



This work was supported by the National Natural Science Foundation of China (No. 30973578 and No. 30973673) and the State Science and Technology Commission (Grant 2001BA701A07-14).


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Jianfeng Xing
    • 1
  • Jinyao Sun
    • 2
  • Haisheng You
    • 2
  • Jun Lv
    • 2
  • Jianning Sun
    • 3
  • Yalin Dong
    • 2
  1. 1.Department of Pharmacy, College of MedicineXi’an Jiaotong UniversityXi’anChina
  2. 2.Department of Pharmacy, the First Affiliated Hospital of Medical CollegeXi’an Jiaotong UniversityXi’anChina
  3. 3.Beijing University of Traditional Chinese MedicineBeijingChina

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