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Increased Interleukin-8 in Epithelial Lining Fluid of Collapsed Lungs During One-Lung Ventilation for Thoracotomy

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Abstract

The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung tumors. The samples were taken after induction of anesthesia (baseline), 30 min after one-lung ventilation was started (point 2), just before resuming two-lung ventilation (point 3), and 30 min after two-lung ventilation was restarted (point 4). The albumin and IL-8 concentrations in ELF were significantly increased at point 2 and point 3, respectively, and remained to be high, compared to the baseline. The increase in IL-8 at point 3 was correlated with the interval of one-lung ventilation; however, none developed specific acute lung injury. These findings suggest that inflammatory changes can occur on the epithelium of a collapsed lung even in patients who underwent successful and standard thoracic surgery.

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Conflict of Interest

There are no conflicts of interest for this study.

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Authors and Affiliations

  1. First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Nagano, 390-8621, Japan

    Yoshimichi Komatsu, Hiroshi Yamamoto, Kenji Tsushima, Shino Furuya, Sumiko Yoshikawa, Masanori Yasuo & Keishi Kubo

  2. Department of Clinical Laboratory, Shinshu University School of Medicine, Matsumoto, Japan

    Yoshitaka Yamazaki

  3. Department of Anesthesiology, Shinshu University School of Medicine, Matsumoto, Japan

    Joh Hasegawa

  4. Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan

    Takashi Eguchi, Ryuichi Kondo & Kazuo Yoshida

  5. Comprehensive Cancer Center, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

    Tomonobu Koizumi

Authors
  1. Yoshimichi Komatsu
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  2. Hiroshi Yamamoto
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  3. Kenji Tsushima
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  4. Shino Furuya
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  5. Sumiko Yoshikawa
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  6. Masanori Yasuo
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  7. Keishi Kubo
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  8. Yoshitaka Yamazaki
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  9. Joh Hasegawa
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  10. Takashi Eguchi
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  11. Ryuichi Kondo
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  12. Kazuo Yoshida
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  13. Tomonobu Koizumi
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Correspondence to Tomonobu Koizumi.

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Komatsu, Y., Yamamoto, H., Tsushima, K. et al. Increased Interleukin-8 in Epithelial Lining Fluid of Collapsed Lungs During One-Lung Ventilation for Thoracotomy. Inflammation 35, 1844–1850 (2012). https://doi.org/10.1007/s10753-012-9505-y

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  • DOI: https://doi.org/10.1007/s10753-012-9505-y

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