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Inflammation

, Volume 35, Issue 4, pp 1419–1428 | Cite as

Elevated Plasma Platelet Activating Factor, Platelet Activating Factor Acetylhydrolase Levels and Risk of Coronary Heart Disease or Blood Stasis Syndrome of Coronary Heart Disease in Chinese: A Case Control Study

A Case–Control Study
  • Guo-Hua Zheng
  • Shang-Quan Xiong
  • Li-Juan Mei
  • Hai-Ying Chen
  • Ting Wang
  • Jian-Feng Chu
Article

Abstract

The purpose of the study was to explore the association between plasma platelet activating factor (PAF) and platelet activating factor acetylhydrolase (PAF-AH) levels and risk of coronary heart disease (CHD) or blood stasis syndrome (BSS) of CHD. Questionnaire, routine clinical assays and plasma levels of PAF, PAF-AH and inflammatory factors hs-CRP and IL-6 were investigated or measured for 120 controls and 150 CHD patients (66 non-BSS and 84 BSS). Plasma PAF levels were higher in CHD patients [49.7 (34.8–73.2 pg/mL)] than in controls [23.8 (14.9–42.3 pg/mL)] (P < 0.001), and in BSS [56.0 (40.1–86.1 pg/mL)] than in non-BSS [47.4 (29.0–67.4 pg/mL)] (P = 0.027). Similarly, plasma PAF-AH levels were higher in CHD patients [11.5 (7.5–15.6 μmol/L)] than in controls [8.1 (5.4–12.6 μmol/L)] (P < 0.001), and in BSS [13.4 (8.7–18.5 μmol/L)] than in non-BSS [9.5 (7.3–14.3 μmol/L)] (P = 0.014). After adjustment for the confounded effects of inflammatory factors or conventional risk factors, plasma PAF and PAF-AH levels still had a significant difference between CHD patients and controls, but plasma PAF-AH rather than PAF levels had a significant difference between BSS and non-BSS. Elevated plasma PAF level contributed to the risk of CHD rather than BSS, and elevated plasma PAF-AH level was an independent risk factor of CHD and BSS.

KEY WORDS

platelet activating factor platelet activating factor acetylhydrolase coronary heart disease blood stasis syndrome risk factor 

Abbreviations

APTT

Activated partial thromboplastin time

BMI

Body mass index

BSS

Blood stasis syndrome

CHD

Coronary heart disease

95 % CI

95 % confidence interval

ECG

Electrocardiography

ELSA

Enzyme-linked immunosorbent assay

HDL-C

High density lipoprotein cholesterol

hs-CRP

High sensitivity C-reaction protein

IL-6

Interleukin 6

LDL-C

Low density lipoprotein cholesterol

LP-PLA2

Lipoprotein-associated phospholipase A2

OR

Odds ratio

PAF

Platelet activating factor

PAF-AH

Platelet activating factor acetylhydrolase

PT

Prothrombin time

SD

Standard deviation

TC

Total cholesterol

TCM

Traditional Chinese medicine

TG

Triglycerides

Notes

Acknowledgments

This study was supported by research funds from the National Natural Science Foundation of China (grant No: 81072726, National Natural Science Foundation of China, Beijing, China) and the Natural Science Foundation of Fujian province (grant No. 2009J01163, Fujian Provincial Department of Science and Technology, Fujian, China).

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Guo-Hua Zheng
    • 1
  • Shang-Quan Xiong
    • 2
  • Li-Juan Mei
    • 1
  • Hai-Ying Chen
    • 1
  • Ting Wang
    • 2
  • Jian-Feng Chu
    • 1
  1. 1.Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhouChina
  2. 2.Department of Cardiologic MedicineThe People’s Hospital of Fujian ProvinceFuzhouChina

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