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Fructose-1,6-Bisphosphate Reduces the Mortality in Candida albicans Bloodstream Infection and Prevents the Septic-Induced Platelet Decrease

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Abstract

Due to the fact that an increased number of patients have experienced bloodstream infections caused by Candida species and the high mortality of this infection, there is a need for a strategy to reduce this scenery. One possible strategy is the use of new drugs, such as fructose-1,6-bisphosphate (FBP), which is a high-energy glycolytic metabolite and has shown to have therapeutic effects in several pathological conditions such as ischemia, shock, toxic injuries, and bacterial sepsis. The aim of this manuscript was to determine the role of FBP in experimental Candida albicans bloodstream infection. We used mice that were divided into three experimental groups: sham (not induced), bloodstream infection (induced with intratracheal instillation of C. albicans) and FBP (bloodstream infection plus FBP 500 mg/kg i.p.). Blood was taken for assessment of complete hematological profile and cytokine assay (IL-6 and MCP-1). Results of the study demonstrated that mortality decreased significantly in groups that received FBP. All cytokine and hematological indexes of FBP group were similar to bloodstream infection group with exception of platelets count. FBP significantly prevented the decrease in platelets. Taken together, our results demonstrate that FBP prevented the mortality in C. albicans bloodstream infection.

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ACKNOWLEDGMENTS

This study was supported by grants from FAPERGS and CAPES/DGU (BEX 4422/09-0 and BEX3449/11-4), Brazil; Institut d’Investigació Biomèdica de Bellvitge (IDIBELL); and Secretaría de Estado de Universidades, Ministerio de Ciencia e Innovación (PHB2008-0080-PC), Spain.

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Authors and Affiliations

  1. Laboratório de Microbiologia Clínica, Ciências da Saúde, Centro Universitário Franciscano, UNIFRA, Rua dos Andradas 1614, sala 115, 97010-032, Santa Maria, Rio Grande do Sul, Brazil

    Roberto Christ Vianna Santos & Ricardo Obalski de Mello

  2. Laboratório de Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Rio Grande do Sul, Brazil

    Roberto Christ Vianna Santos, Patrícia Scherer, Henrique Bregolin Dias & Jarbas Rodrigues de Oliveira

  3. Unitat Bioquímica i Biologia Molecular, Departament de Ciències Fisiològiques II, IDIBELL, Campus de Bellvitge, Universitat de Barcelona, Barcelona, Spain

    Roberto Christ Vianna Santos, Miguel Angel Peña Rico, Antonio R. García Susperregui, Jose Luis Rosa, Ramon Bartrons, Francesc Ventura & Jarbas Rodrigues de Oliveira

  4. Laboratório de Bioquímica Clínica, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, USFM, Santa Maria, RS, Brazil

    Rafael Noal Moresco, Etiane Tatsch & Helena Kober

  5. Laboratório de Pesquisas Micológicas, Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, UFSM, Santa Maria, RS, Brazil

    Débora Nunes Mário & Sydney Hartz Alves

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  1. Roberto Christ Vianna Santos
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  2. Rafael Noal Moresco
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Correspondence to Roberto Christ Vianna Santos.

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Santos, R.C.V., Moresco, R.N., Peña Rico, M.A. et al. Fructose-1,6-Bisphosphate Reduces the Mortality in Candida albicans Bloodstream Infection and Prevents the Septic-Induced Platelet Decrease. Inflammation 35, 1256–1261 (2012). https://doi.org/10.1007/s10753-012-9436-7

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