, Volume 35, Issue 4, pp 1251–1255 | Cite as

Serum Amyloid A Levels Associated with Gastrointestinal Manifestations in Henoch-Schönlein Purpura

  • Xuelian He
  • Yulan Zhao
  • Yin Li
  • Shixiu Kang
  • Yan Ding
  • Jiangwei Luan
  • Peiwei Zhao
  • Ningsheng Liu
  • Wei Yin


Henoch-Schönlein purpura (HSP) is considered as an immune-mediated inflammatory disease. Serum amyloid A (SAA) is an acute-phase protein with proinflammatory effects. We investigated the levels of SAA in HSP patients and examined whether SAA levels are associated with organ involvement and disease severity. Seventy patients with HSP, including 35 with nephritis (HSPN) and 35 without HSPN, and 20 controls were recruited in our study. SAA levels were measured and other clinical laboratory parameters, including C-reactive protein, erythrocyte sedimentation rate, complement 3 (C3), C4, and immunoglobulin (Ig) A, were recorded. SAA levels were not found to be independently associated with renal, joint involvement, and disease severity. However, higher SAA levels were observed in HSP patients with gastrointestinal (GI) manifestations (p = 0.006, p c  = 0.048). Moreover, the levels of SAA were significantly associated with duration of disease (p < 0.005, p c  < 0.04). Our findings suggested that SAA was significantly associated with disease duration and GI manifestations in HSP patients.


Henoch-Schönlein purpura acute-phase protein serum amyloid A disease severity 



This study was funded by the supporting program of the Ministry of Human Resource of China Oversea Returned scholars.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Xuelian He
    • 1
  • Yulan Zhao
    • 2
  • Yin Li
    • 1
  • Shixiu Kang
    • 1
  • Yan Ding
    • 1
  • Jiangwei Luan
    • 1
  • Peiwei Zhao
    • 1
  • Ningsheng Liu
    • 3
  • Wei Yin
    • 1
  1. 1.Wuhan Children’s HospitalWuhanPeople’s Republic of China
  2. 2.Institutes for Advanced Interdisciplinary ResearchEast China Normal UniversityShanghaiPeople’s Republic of China
  3. 3.Department of PathologyNanjing Medical UniversityNanjingPeople’s Republic of China

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