, Volume 35, Issue 2, pp 399–404 | Cite as

Salivary and Serum Interleukin-18 in Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

  • Yuanyuan Zhang
  • Wenzhao Liu
  • Songtao Zhang
  • Hongxia Dan
  • Rui Lu
  • Fang Wang
  • Jing Wang
  • Min Zhou
  • Xin Zeng
  • Mei Lin
  • Qianming Chen
  • Yu Zhou


The purpose of this study was to investigate the potential pro-inflammatory role of the cytokine interleukin (IL-18) in oral lichen planus (OLP) so as to provide a reliable and early indicator for the diagnosis of OLP. One hundred three ethnic Chinese patients with OLP were enrolled in this study, as were 48 age- and sex-matched controls. IL-18 concentrations in serum and saliva were screened by enzyme-linked immunosorbent assay. The protein content was expressed as picograms per milliliter. OLP patients showed a high-level of IL-18 expression profile in serum compared with the control group (OLP = 21.32 ± 8.26 pg/mL, control = 12.29 ± 5.11 pg/mL, P < 0.05), and the saliva partner had significantly higher concentrations of IL-18 compared to the control (OLP = 20.12 ± 5.78 pg/mL, control = 15.60 ± 4.17 pg/mL, P < 0.05). In patients with OLP, serum and salivary IL-18 are elevated, correlating with the severity of illness. These findings may be considered to improve the predictive or prognostic values of inflammatory cytokines for OLP and also to design possible novel therapeutic approaches.


oral lichen planus pathogenesis cytokines serum saliva 



This work was supported by the National Natural Science Foundation of China (no. 30930100 and 30772424), the National Science Funds for Talented Professionals (30725041), and the Scientific Research Foundation for Medicine and Health Bureau of Henan Province (no. 201003067).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Yuanyuan Zhang
    • 1
  • Wenzhao Liu
    • 2
  • Songtao Zhang
    • 3
  • Hongxia Dan
    • 4
  • Rui Lu
    • 4
  • Fang Wang
    • 4
  • Jing Wang
    • 4
  • Min Zhou
    • 4
  • Xin Zeng
    • 4
  • Mei Lin
    • 4
  • Qianming Chen
    • 4
  • Yu Zhou
    • 4
  1. 1.Department of Oral Medicine, College of StomatologyZhengzhou UniversityZhengzhouChina
  2. 2.School & Hospital of StomatologyWenzhou Medical CollegeWenzhouChina
  3. 3.Department of Head and Neck Oncology SurgeryHenan Province Tumor HospitalZhengzhouChina
  4. 4.State Key Laboratory of Oral Diseases, West China College of StomatologySichuan UniversityChengduChina

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