, Volume 35, Issue 1, pp 183–191 | Cite as

Effect of Scrophularia buergeriana Extract on the Degranulation of Mast Cells and Ear Swelling Induced by Dinitrofluorobenzene in Mice

  • Jin-Kyung Kim
  • Yoon Hee Kim
  • Hee Hwan Lee
  • Soon Sung Lim
  • Kyung Woo Park


Scrophularia buergeriana Miquel (Scrophulariaceae, SB) is a biennial plant native to Korea, northern China, and Japan that plays an important role in traditional medicine. The dried root of SB has long been used in oriental medicine for treatment of fever, swelling, constipation, pharyngitis, neuritis, and laryngitis. In the present study, we evaluated the ethanol extract of SB (SBE) to determine if it exerted any anti-allergic effects that had not previously been demonstrated. SBE markedly inhibited β-hexosaminidase and histamine release and suppressed the expression of tumor necrosis factor-α and interleukin-4 cytokines by RBL-2H3 mast cells. In addition, topical treatment with SBE effectively reduced allergic inflammation in a dinitrofluorobenzene-induced contact hypersensitivity mouse model. These results strongly suggest that SBE is a promising source of anti-allergic agents.


Scrophularia buergeriana allergy inflammation RBL-2H3 cell 



This research was supported by research grants from Catholic University of Daegu in 2010.

Supplementary material

10753_2011_9304_MOESM1_ESM.doc (320 kb)
Supplementary Fig. 1 (DOC 319 kb)


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Jin-Kyung Kim
    • 1
    • 4
  • Yoon Hee Kim
    • 2
  • Hee Hwan Lee
    • 2
  • Soon Sung Lim
    • 3
  • Kyung Woo Park
    • 1
  1. 1.Department of Biomedical ScienceCatholic University of DaeguGyeongsan-SiSouth Korea
  2. 2.Center for Efficacy Assessment and Development of Functional Foods and DrugsHallym UniversityChuncheonSouth Korea
  3. 3.Department of Food Science and NutritionHallym UniversityChuncheonSouth Korea
  4. 4.Department of Biomedical ScienceGyeongsan-SiSouth Korea

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