, Volume 34, Issue 5, pp 402–411 | Cite as

Beneficial Effect of Eucommia Polysaccharides on Systemic Lupus Erythematosus-like Syndrome Induced by Campylobacter jejuni in BALB/c Mice

  • Long Jiang
  • Zheng Wang
  • Hong-Wei Zhu
  • Hong-Ye Di
  • Hong Li
  • Yun-Yi Zhang
  • Dao-Feng Chen


The stem bark of Eucommia ulmoides Oliv. is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia in traditional Chinese medicine. This study was to determine whether the crude polysaccharides (EUPs) isolated from the stem bark of E. ulmoides had beneficial effects on lupus-like syndrome in mice. BALB/c mice were immunized with CJ-S131 in Freund’s complete adjuvant on day 0, and then boosted on day 14. EUPs 15 or 30 mg kg−1·day−1, or prednisone 5 mg kg−1·day−1 was given to BALB/c mice intragastrically from day 0 to 34. Treatment with EUPs 15 or 30 mg kg−1·day−1 for 35 days protected kidney from glomerular injury with reduced immunoglobulin deposition and lowered proteinuria. The increased production of serum autoantibodies and total immunoglobulin G (IgG) was also inhibited. These findings suggested that Eucommia polysaccharides had a beneficial effect on systemic lupus erythematosus-like syndrome induced by CJ-S131 in BALB/c mice.


systemic lupus erythematosus (SLE) polysaccharides Eucommia ulmoides autoantibody Campylobacter jejuni autoimmunity 



Eucommia polysaccharides

E. ulmoides

Eucommia ulmoides Oliv.


Systemic lupus erythematosus


Immunoglobulin G


Campylobacter jejuni


Normal saline


Carboxymethyl cellulose


Enzyme-linked immunosorbent assay


Sheep red blood cells


Barbital buffer solution


Nitric oxide


Freund’s complete adjuvant


Bacillus Calmette–Guerin


Horseradish peroxides


3-3 diaminobenzidine



This work was supported by the Natural Science Foundation of China (30925042 and 30572315), the State Key Program from the Ministry of Science and Technology, China (2009ZX09502–013; 2009ZX09313-008), and Science and Technology Commission of Shanghai Municipality (10XD1405900), awarded to D.F. Chen.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Long Jiang
    • 1
  • Zheng Wang
    • 1
  • Hong-Wei Zhu
    • 2
  • Hong-Ye Di
    • 2
  • Hong Li
    • 1
  • Yun-Yi Zhang
    • 1
  • Dao-Feng Chen
    • 2
  1. 1.Department of Pharmacology, School of PharmacyFudan UniversityShanghaiChina
  2. 2.Department of Pharmacognosy, School of PharmacyFudan UniversityShanghaiChina

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