Plasma Levels of C-Telopeptide Pyridinoline Cross-Links of Type I Collagen and Osteocalcin in Chronic Periodontitis
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This study was planned to investigate whether chronic periodontitis patients exhibit different plasma concentrations of C-telopeptide pyridinoline cross-links of type I collagen (ICTP) and osteocalcin (OC) compared to the clinically healthy controls. Before initiation of any periodontal intervention, plasma samples and full-mouth clinical periodontal recordings were obtained from 58 otherwise healthy patients with chronic periodontitis and also from 47 systemically and periodontally healthy control subjects. Plasma ICTP levels were determined by radioimmunoassay and OC levels by enzyme-linked immunosorbent assay. Data were tested statistically using t test and ANOVA. The healthy control group exhibited significantly lower values in all clinical periodontal measurements (P < 0.001). There were no significant differences between the study groups in plasma ICTP and OC levels (P > 0.05). Within the limits of this study, it may be suggested that plasma levels of ICTP and OC may not provide distinguishing data between chronic periodontitis patients and clinically healthy subjects.
KEY WORDSICTP inflammation osteocalcin periodontal disease plasma
Source of Funding
This study has been funded solely by the institutions of the authors.
Conflict of Interest
The authors declare that they have no conflict of interest.
- 6.Oringer, R.J., M.D. Palys, A. Iranmanesh, J.P. Fiorellini, A.D. Haffajee, S.S. Socransky, and W.V. Giannobile. 1998. C-telopeptide pyridinoline cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants. Clinical Oral Implants Research 9: 365–373.PubMedCrossRefGoogle Scholar
- 12.Buduneli, E., N. Buduneli, S. Vardar-Şengül, L. Kardeşler, G. Atilla, D. Lappin, and D.F. Kinane. 2005. Systemic low-dose doxycycline and alendronate administration and serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. Journal of Periodontology 76: 1927–1933.PubMedCrossRefGoogle Scholar
- 13.Tümer, C., Y. Aksoy, G.N. Güncü, R.M. Nohutçu, K. Kılınç, and T.F. Tözüm. 2008. Possible impact of inflammatory status on C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels around oral implants with peri-implantitis: a controlled clinical trial. Journal of Oral Rehabilitation 35: 934–939.PubMedCrossRefGoogle Scholar
- 14.Oringer, R.J., K.F. Al-Shammari, and D.P. Sarment. 2003. Matrix molecules and growth factors as indicators of periodontal disease activity. Periodontology 2000 31: 125–134.Google Scholar
- 16.Bullon, P., B. Goberna, J.M. Guerro, J.J. Segura, R. Parez-Cano, and A. Martinez-Sahuguillo. 2005. Serum, saliva and gingival crevicular fluid osteocalcin: their relation to periodontal status and bone mineral density in postmenopausal women. Journal of Periodontology 76: 513–519.PubMedCrossRefGoogle Scholar
- 20.Murata, M., J. Tatsumi, Y. Kato, S. Suda, Y. Nunokawa, Y. Kobayashi, H. Takeda, H. Araki, K. Shin, K. Okuda, T. Miyata, and H. Yoshie. 2002. Osteocalcin, deoxypyridinoline and interleukin-1beta in peri-implant crevicular fluid of patients with peri-implantitis. Clinical Oral Implants Research 13: 637–643.PubMedCrossRefGoogle Scholar