, Volume 32, Issue 4, pp 211–217 | Cite as

Inhibitory Effect of Glycoprotein Isolated from Cudrania tricuspidata Bureau on Expression of Inflammation-Related Cytokine in Bisphenol A-Treated HMC-1 Cells

  • Jae-Uoong Shim
  • Kye-Taek Lim


Cudrania tricuspidata is one of the most omnipresent traditional herbal drugs for anti-inflammation and anti-tumor. The purpose of the present study was to determine whether the CTB glycoprotein regulates the inflammatory reaction stimulated by bisphenol A (BPA) in human mast cells (HMC-1). Thus, we investigated that CTB glycoprotein inhibits the degranulation of histamine, expression of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), as a mitogen activated protein (MAP) kinase, nuclear transcription factors involving nuclear factor (NF)-κB and Activator protein (AP)-1, cyclooxygenase (COX)-2. The results indicated that CTB glycoprotein decreased gene expression of cytokines of IL-4, IFN-γ, interleukin (IL)-1β and cyclooxygenase (COX)-2 in BPA-stimulated HMC-1 cells. Hence, we speculate that CTB glycoprotein can use as a potent anti-inflammatory agent for inflammatory allergic diseases.


CTB glycoprotein IL-4 IFN-γ IL-1β inflammation HMC-1 cells bisphenol A 



This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund; KRF-2008-521-C00167).


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Molecular Biochemistry Laboratory, Biotechnology Research InstituteChonnam National UniversityGwangju CitySouth Korea

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