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Regulatory Effects of Cytokine Production in Atopic Allergic Reaction by Gammi-Danguieumja

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Abstract

Gammi-danguieumja (GD) is clinically used in South Korea for treating atopic dermatitis. However, its effects in experimental models remain unknown. We investigated a possible effect of GD on cytokines production using human T cell line (MOLT-4) or human mast cell line. As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-γ, and decreased IL-4 secretion in MOLT-4. GD (0.01–1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1. In addition, GD inhibited histamine release from activated mast cells. These results suggest that GD contributes to the regulation of atopic allergic reactions.

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Authors and Affiliations

  1. College of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea

    Ho-Jeong Na, Hye-Young Shin, Na-Hyung Kim, Nam-Il Kim & Hyung-Min Kim

  2. College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea

    Na-Hyung Kim & Seung-Heon Hong

  3. College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea

    Mi-Won Kwon & Eun-Jeong Park

  4. Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea

    Hyung-Min Kim

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Na, HJ., Shin, HY., Kim, NH. et al. Regulatory Effects of Cytokine Production in Atopic Allergic Reaction by Gammi-Danguieumja. Inflammation 28, 291–298 (2004). https://doi.org/10.1007/s10753-004-6053-0

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