, Volume 28, Issue 5, pp 291–298 | Cite as

Regulatory Effects of Cytokine Production in Atopic Allergic Reaction by Gammi-Danguieumja

  • Ho-Jeong Na
  • Hye-Young Shin
  • Na-Hyung Kim
  • Mi-Won Kwon
  • Eun-Jeong Park
  • Seung-Heon Hong
  • Nam-Il Kim
  • Hyung-Min Kim


Gammi-danguieumja (GD) is clinically used in South Korea for treating atopic dermatitis. However, its effects in experimental models remain unknown. We investigated a possible effect of GD on cytokines production using human T cell line (MOLT-4) or human mast cell line. As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-γ, and decreased IL-4 secretion in MOLT-4. GD (0.01–1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1. In addition, GD inhibited histamine release from activated mast cells. These results suggest that GD contributes to the regulation of atopic allergic reactions.

Key Words

Gammi-danguieumja atopic dermatitis cytokines histamine 


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Copyright information

© Springer Science + Business Media, Inc. 2004

Authors and Affiliations

  • Ho-Jeong Na
    • 1
  • Hye-Young Shin
    • 1
  • Na-Hyung Kim
    • 1
    • 2
  • Mi-Won Kwon
    • 3
  • Eun-Jeong Park
    • 3
  • Seung-Heon Hong
    • 2
  • Nam-Il Kim
    • 1
  • Hyung-Min Kim
    • 1
    • 4
  1. 1.College of Oriental MedicineKyung Hee UniversitySeoulSouth Korea
  2. 2.College of PharmacyWonkwang UniversityIksanSouth Korea
  3. 3.College of Oriental MedicineWonkwang UniversityIksanSouth Korea
  4. 4.Department of PharmacologyCollege of Oriental Medicine, Kyung Hee UniversitySeoulSouth Korea

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