Efficiency analysis of clearance of two types of exogenous iron from the rat brain by Mössbauer spectroscopy
Fe3O4 based ferrofluid was injected transcranially in the ventricle of the rat brain. At 3 months after the injection the rat was sacrificed and the brain was investigated by Mössbauer spectroscopy and histological Perls Prussian blue method. Joint analysis of histological and Mössbauer data confirms that superparamagnetic nanoparticles Fe3O4, which constituted about 91 % of the iron of the ferrofluid, were cleared from the brain, while the concomitant chemical compound containing ferric ion in the high-spin state, remains intact.
KeywordsMössbauer spectroscopy Magnetic nanoparticles Brain
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- 2.Chuev, M.A., Hesse, J.: Non-Equilibrium magnetism of single-domain particles for characterization of magnetic nanomaterials. In: Tamayo, K.B. (ed.) Magnetic Properties of Solids, pp. 1–104. Nova Science Publishers, New York (2009)Google Scholar
- 12.Paxinos G., Watson, C.: The Rat Brain in Stereotaxic Coordinates. Academic Press (1998)Google Scholar