Human Physiology

, Volume 31, Issue 1, pp 114–116 | Cite as

Contribution of α-adrenoceptors to the contractility of the human myocardium in chronic coronary heart disease

  • S. A. Afanas’ev
  • D. S. Ugdyzhekova
  • R. S. Karpov
Short Communications


The inotropic response of isolated myocardial strips to α1-adrenoceptor stimulation was compared for patients with chronic coronary heart disease (CHD) and patients with WPW syndrome. The α1-adrenoceptors were stimulated with 1 × 10 M phenylephrine after blocking of the β-adrenoceptors with 3 × 10−1 M propranolol. The inotropic activity was recorded in the isometric mode. In the myocardium without signs of ischemic damage, stimulation of the α1-receptors caused a slowly developing single-phase positive inotropic response. The myocardium of the CHD patients was characterized by a three-phase response. The specific features of the inotropic response to α1-adrenoceptor stimulation in the CHD patients were assumed to be determined by changes in intracellular homeostasis of Ca2+. Electromechanical coupling in cardiac myocytes of CHD patients depends on Ca2+ deposited in the sarcoplasmic reticulum to a greater extent than coupling in the intact myocardium. An additional positive inotropic effect is possible upon exogenous calcium influx into cardiac myocytes.


Propranolol Sarcoplasmic Reticulum Cardiac Myocytes Phenylephrine Electromechanical Coupling 
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Copyright information

© MAIK “Nauka/Interperiodica” 2005

Authors and Affiliations

  • S. A. Afanas’ev
    • 1
  • D. S. Ugdyzhekova
    • 1
  • R. S. Karpov
    • 1
  1. 1.Institute of Cardiology, Tomsk Research Center, Siberian DivisionRussian Academy of SciencesTomskRussia

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