Abstract
The inotropic response of isolated myocardial strips to α1-adrenoceptor stimulation was compared for patients with chronic coronary heart disease (CHD) and patients with WPW syndrome. The α1-adrenoceptors were stimulated with 1 × 10− M phenylephrine after blocking of the β-adrenoceptors with 3 × 10−1 M propranolol. The inotropic activity was recorded in the isometric mode. In the myocardium without signs of ischemic damage, stimulation of the α1-receptors caused a slowly developing single-phase positive inotropic response. The myocardium of the CHD patients was characterized by a three-phase response. The specific features of the inotropic response to α1-adrenoceptor stimulation in the CHD patients were assumed to be determined by changes in intracellular homeostasis of Ca2+. Electromechanical coupling in cardiac myocytes of CHD patients depends on Ca2+ deposited in the sarcoplasmic reticulum to a greater extent than coupling in the intact myocardium. An additional positive inotropic effect is possible upon exogenous calcium influx into cardiac myocytes.
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Translated from Fiziologiya Cheloveka, Vol. 31, No. 1, 2005, pp. 133–136.
Original Russian Text Copyright © 2005 by Afanas’ev, Ugdyzhekova, Karpov.
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Afanas’ev, S.A., Ugdyzhekova, D.S. & Karpov, R.S. Contribution of α-adrenoceptors to the contractility of the human myocardium in chronic coronary heart disease. Hum Physiol 31, 114–116 (2005). https://doi.org/10.1007/s10747-005-0016-1
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DOI: https://doi.org/10.1007/s10747-005-0016-1