Abstract
There have been increasing concerns about the unexpected effects of right ventricular (RV) pacing. We aimed to systematically evaluate the effect of biventricular (BiV) versus RV pacing on clinical events in patients with impaired AV conduction. We searched PubMed, EMBASE, and Cochrane Library for studies comparing BiV pacing with RV pacing in patients with AV block, through April 2017. We selected randomized controlled trials (RCTs) reporting data on mortality, hospitalization for heart failure (HF), and/or 6-min walk distance (6MWD). A total of 12 RCTs were finally included. Pooled analysis suggested that BiV pacing was associated with a significantly reduced all-cause mortality in contrast to RV pacing (risk ratio (RR) = 0.77, 95% confidence interval (CI) 0.62 to 0.95, I2 = 9.6%). BiV pacing, compared with RV pacing, significantly reduced the rate of HF hospitalization (RR = 0.74, 95% CI 0.59 to 0.93, I2 = 10.1%). Sensitivity analyses by excluding studies with AV nodal ablation showed that BiV pacing still had a lower mortality and non-significant reduced HF hospitalization. Patients in BiV and RV pacing mode had a similar 6WMD at follow-up (mean difference = 4.99 m, 95% CI − 11.34 to 21.33 m, I2 = 0%). Meta-regression analysis showed that the effect size of all-cause mortality or HF hospitalization was not significantly associated with mean LVEF value at baseline. In patients with impaired AV conduction that need frequent ventricular pacing, BiV pacing was associated with reduced mortality and hospitalization for HF, compared with traditional RV pacing mode.
Similar content being viewed by others
References
Thackray SD, Witte KK, Nikitin NP, Clark AL, Kaye GC, Cleland JG (2003) The prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in a typical regional pacemaker population. Eur Heart J 24(12):1143–1152
Liu WH, Chen MC, Chen YL, Guo BF, Pan KL, Yang CH, Chang HW (2008) Right ventricular apical pacing acutely impairs left ventricular function and induces mechanical dyssynchrony in patients with sick sinus syndrome: a real-time three-dimensional echocardiographic study. J Am Soc Echocardiogr 21(3):224–229. https://doi.org/10.1016/j.echo.2007.08.045
Wilkoff BL, Cook JR, Epstein AE, Greene HL, Hallstrom AP, Hsia H, Kutalek SP, Sharma A (2002) Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the dual chamber and VVI implantable defibrillator (DAVID) trial. JAMA 288(24):3115–3123
Frohlig G, Gras D, Victor J, Mabo P, Galley D, Savoure A, Jauvert G, Defaye P, Ducloux P, Amblard A (2006) Use of a new cardiac pacing mode designed to eliminate unnecessary ventricular pacing. Europace 8(2):96–101. https://doi.org/10.1093/europace/euj024
Savoure A, Frohlig G, Galley D, Defaye P, Reuter S, Mabo P, Sadoul N, Amblard A, Limousin M, Anselme F (2005) A new dual-chamber pacing mode to minimize ventricular pacing. Pacing Clin Electrophysiol 28(Suppl 1):S43–S46. https://doi.org/10.1111/j.1540-8159.2005.00095.x
Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, Tavazzi L (2005) The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 352(15):1539–1549. https://doi.org/10.1056/NEJMoa050496
Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, Estes NA 3rd, Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W (2009) Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med 361(14):1329–1338. https://doi.org/10.1056/NEJMoa0906431
Yu CM, Chan JY, Zhang Q, Omar R, Yip GW, Hussin A, Fang F, Lam KH, Chan HC, Fung JW (2009) Biventricular pacing in patients with bradycardia and normal ejection fraction. N Engl J Med 361(22):2123–2134. https://doi.org/10.1056/NEJMoa0907555
Orlov MV, Gardin JM, Slawsky M, Bess RL, Cohen G, Bailey W, Plumb V, Flathmann H, de Metz K (2010) Biventricular pacing improves cardiac function and prevents further left atrial remodeling in patients with symptomatic atrial fibrillation after atrioventricular node ablation. Am Heart J 159(2):264–270. https://doi.org/10.1016/j.ahj.2009.11.012
Brignole M, Botto G, Mont L, Iacopino S, De Marchi G, Oddone D, Luzi M, Tolosana JM, Navazio A, Menozzi C (2011) Cardiac resynchronization therapy in patients undergoing atrioventricular junction ablation for permanent atrial fibrillation: a randomized trial. Eur Heart J 32(19):2420–2429. https://doi.org/10.1093/eurheartj/ehr162
Curtis AB, Worley SJ, Adamson PB, Chung ES, Niazi I, Sherfesee L, Shinn T, Sutton MS (2013) Biventricular pacing for atrioventricular block and systolic dysfunction. N Engl J Med 368(17):1585–1593. https://doi.org/10.1056/NEJMoa1210356
Leclercq C, Walker S, Linde C, Clementy J, Marshall AJ, Ritter P, Djiane P, Mabo P, Levy T, Gadler F, Bailleul C, Daubert JC (2002) Comparative effects of permanent biventricular and right-univentricular pacing in heart failure patients with chronic atrial fibrillation. Eur Heart J 23(22):1780–1787
Brignole M, Gammage M, Puggioni E, Alboni P, Raviele A, Sutton R, Vardas P, Bongiorni MG, Bergfeldt L, Menozzi C, Musso G (2005) Comparative assessment of right, left, and biventricular pacing in patients with permanent atrial fibrillation. Eur Heart J 26(7):712–722. https://doi.org/10.1093/eurheartj/ehi069
Doshi RN, Daoud EG, Fellows C, Turk K, Duran A, Hamdan MH, Pires LA (2005) Left ventricular-based cardiac stimulation post AV nodal ablation evaluation (the PAVE study). J Cardiovasc Electrophysiol 16(11):1160–1165. https://doi.org/10.1111/j.1540-8167.2005.50062.x
Kindermann M, Hennen B, Jung J, Geisel J, Bohm M, Frohlig G (2006) Biventricular versus conventional right ventricular stimulation for patients with standard pacing indication and left ventricular dysfunction: the Homburg Biventricular Pacing Evaluation (HOBIPACE). J Am Coll Cardiol 47(10):1927–1937. https://doi.org/10.1016/j.jacc.2005.12.056
Martinelli Filho M, de Siqueira SF, Costa R, Greco OT, Moreira LF, D'Avila A, Heist EK (2010) Conventional versus biventricular pacing in heart failure and bradyarrhythmia: the COMBAT study. J Card Fail 16(4):293–300. https://doi.org/10.1016/j.cardfail.2009.12.008
Albertsen AE, Mortensen PT, Jensen HK, Poulsen SH, Egeblad H, Nielsen JC (2011) Adverse effect of right ventricular pacing prevented by biventricular pacing during long-term follow-up: a randomized comparison. Eur J Echocardiogr 12(10):767–772. https://doi.org/10.1093/ejechocard/jer136
Stockburger M, Gomez-Doblas JJ, Lamas G, Alzueta J, Fernandez-Lozano I, Cobo E, Wiegand U, Concha JF, Navarro X, Navarro-Lopez F, de Teresa E (2011) Preventing ventricular dysfunction in pacemaker patients without advanced heart failure: results from a multicentre international randomized trial (PREVENT-HF). Eur J Heart Fail 13(6):633–641. https://doi.org/10.1093/eurjhf/hfr041
Yu CM, Fang F, Luo XX, Zhang Q, Azlan H, Razali O (2014) Long-term follow-up results of the pacing to avoid cardiac enlargement (PACE) trial. Eur J Heart Fail 16(9):1016–1025. https://doi.org/10.1002/ejhf.157
Zhang XY, Shan QJ, Su YG, Yan J, Bao ZH, Gu X, Qiu JP, Qin SM, Xu J, Su H, Zhu H, Guo JF, Lu JP, Zou JG, Chen ML, Xu D, Cao KJ (2016) Efficacy of biventricular pacing on preventing heart failure in patients with high degree atrioventricular block (BIVPACE-AVB trial). Zhonghua Xin Xue Guan Bing Za Zhi 44(4):331–337. https://doi.org/10.3760/cma.j.issn.0253-3758.2016.04.011
Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Trupp RJ, Underwood J, Pickering F, Truex C, McAtee P, Messenger J (2002) Cardiac resynchronization in chronic heart failure. N Engl J Med 346(24):1845–1853. https://doi.org/10.1056/NEJMoa013168
Bourke JP, Hawkins T, Keavey P, Tynan M, Jamieson S, Behulova R, Furniss SS (2002) Evolution of ventricular function during permanent pacing from either right ventricular apex or outflow tract following AV-junctional ablation for atrial fibrillation. Europace 4(3):219–228
Victor F, Leclercq C, Mabo P, Pavin D, Deviller A, de Place C, Pezard P, Victor J, Daubert C (1999) Optimal right ventricular pacing site in chronically implanted patients: a prospective randomized crossover comparison of apical and outflow tract pacing. J Am Coll Cardiol 33(2):311–316
Tse HF, Yu C, Wong KK, Tsang V, Leung YL, Ho WY, Lau CP (2002) Functional abnormalities in patients with permanent right ventricular pacing: the effect of sites of electrical stimulation. J Am Coll Cardiol 40(8):1451–1458
de Cock CC, Giudici MC, Twisk JW (2003) Comparison of the haemodynamic effects of right ventricular outflow-tract pacing with right ventricular apex pacing: a quantitative review. Europace 5(3):275–278
Kaye G, Stambler BS, Yee R (2009) Search for the optimal right ventricular pacing site: design and implementation of three randomized multicenter clinical trials. Pacing Clin Electrophysiol 32(4):426–433. https://doi.org/10.1111/j.1540-8159.2009.02301.x
Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL (2013) 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation 128(16):e240–e327. https://doi.org/10.1161/CIR.0b013e31829e8776
Lyons KJ, Ezekowitz JA, Liang L, Heidenreich PA, Yancy CW, DeVore AD, Hernandez AF, Fonarow GC (2017) Impact of current versus previous cardiac resynchronization therapy guidelines on the proportion of patients with heart failure eligible for therapy. JACC Heart Fail 5(5):388–392. https://doi.org/10.1016/j.jchf.2017.02.018
Tracy CM, Epstein AE, Darbar D, Dimarco JP, Dunbar SB, Estes NA 3rd, Ferguson TB Jr, Hammill SC, Karasik PE, Link MS, Marine JE, Schoenfeld MH, Shanker AJ, Silka MJ, Stevenson LW, Stevenson WG, Varosy PD (2012) 2012 ACCF/AHA/HRS focused update of the 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 60(14):1297–1313. https://doi.org/10.1016/j.jacc.2012.07.009
Funck RC, Mueller HH, Lunati M, Piorkowski C, De Roy L, Paul V, Wittenberg M, Wuensch D, Blanc JJ (2014) Characteristics of a large sample of candidates for permanent ventricular pacing included in the Biventricular Pacing for Atrio-ventricular Block to Prevent Cardiac Desynchronization Study (BioPace). Europace 16(3):354–362. https://doi.org/10.1093/europace/eut343
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
This article does not contain any studies with human participants or animals performed by any of the authors.
Electronic supplementary material
ESM 1
(DOCX 1207 kb)
Rights and permissions
About this article
Cite this article
Lu, D., Zhang, H., Chen, C. et al. Clinical outcomes with biventricular versus right ventricular pacing in patients with atrioventricular conduction defects. Heart Fail Rev 23, 897–906 (2018). https://doi.org/10.1007/s10741-018-9699-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10741-018-9699-7