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Clinical applications of N-terminal pro B-type natriuretic peptide in heart failure and other cardiovascular diseases

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Abstract

N-terminal fragment of pro B-type natriuretic peptide (NT-proBNP) has emerged as an important adjunct in the management of heart failure (HF) and other cardiovascular diseases. NT-proBNP is a 76-amino acid peptide created during cleavage of the precursor molecule, Pro B-type natriuretic peptide (ProBNP). NT-proBNP is of significant diagnostic value in patients presenting with possible HF and is an important prognostic factor in this condition and other cardiovascular diseases. Ongoing research supports the potential value of this biomarker in non-cardiovascular disease. This review will describe clinical applications of NT-proBNP in HF and a broad range of other conditions.

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Authors and Affiliations

  1. Department of Ultrasonography, The Second Xiangya Hospital of Central South University, Renming Road, #139, 410011, Changsha, People’s Republic of China

    Da-Rong Pu & Qi-chang Zhou

  2. Cardiomyopathy Program, Loma Linda University Medical Center, Loma Linda, CA, 92354, USA

    Jun R. Chiong

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  1. Da-Rong Pu
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  2. Jun R. Chiong
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Correspondence to Qi-chang Zhou.

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Pu, DR., Chiong, J.R. & Zhou, Qc. Clinical applications of N-terminal pro B-type natriuretic peptide in heart failure and other cardiovascular diseases. Heart Fail Rev 15, 293–304 (2010). https://doi.org/10.1007/s10741-009-9142-1

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