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The treatment of heart failure with preserved ejection fraction (“diastolic heart failure”)

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Abstract

Unlike heart failure with a low ejection fraction, there is no evidence-based treatment for heart failure with preserved ejection fraction which improves clinical outcomes. Indeed, the only evidence for any treatment effect comes from small studies with verapamil where this drug increased exercise capacity and reduced a heart failure score. Large trials are presently underway which are examining the effect of treatment with an ACE inhibitor, ARB and aldosterone antagonist in patients with heart failure and preserved ejection fraction.

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Authors and Affiliations

  1. Department of Cardiology, Clinical Research Initiative in Heart Failure, University of Glasgow Western Infirmary, Glasgow, G11 6NT, United Kingdom

    Karen Hogg & John McMurray

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  1. Karen Hogg
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  2. John McMurray
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Correspondence to John McMurray.

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Hogg, K., McMurray, J. The treatment of heart failure with preserved ejection fraction (“diastolic heart failure”). Heart Fail Rev 11, 141–146 (2006). https://doi.org/10.1007/s10741-006-9488-6

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