Journal of Molecular Histology

, Volume 47, Issue 3, pp 287–295 | Cite as

Overexpression of Dishevelled-2 contributes to proliferation and migration of human esophageal squamous cell carcinoma

  • Guoren Zhou
  • Jinjun Ye
  • Lei Sun
  • Zhi Zhang
  • Jifeng Feng
Original Paper


Dishevelled-2 (Dvl2) was associated with tumor cell proliferation and migration. We aimed to examine the mechanism of Dvl2 in esophageal squamous cell carcinoma (ESCC). Dvl2 was overexpressed in human ESCC tissues and cell lines ECA109 and TE1 cells. CCK-8 and colony formation assay was performed to evaluate the proliferation in ECA109 cells transfected with Dvl2-shRNA. Wound-healing assay and transwell assay were used to examine the activities of migration and invasion in Dvl2-silenced ESCC cells. Knockdown of Dvl2 significantly reduced ECA109 cell proliferation and migration. Moreover, we demonstrated that the proliferation and migration ability of Dvl2 might through the activation of Wnt pathway by targeting the Cyclin D1 and MMP-9. We came to the conclusion that the proliferation and migration effects of Dvl2 might contribute to malignant development of human ESCC.


Esophageal squamous cell carcinoma Dvl2 Wnt signaling activation Proliferation Migration 


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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  1. 1.Department of RadiotherapyJiangsu Cancer Hospital Affiliated to Nanjing Medical UniversityNanjingChina
  2. 2.Department of ChemotherapyJiangsu Cancer Hospital Affiliated to Nanjing Medical UniversityNanjingChina

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