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Journal of Molecular Histology

, Volume 45, Issue 4, pp 421–426 | Cite as

Prognostic significance of TBX2 expression in non-small cell lung cancer

  • Bo Hu
  • Hai-Ping Mu
  • Yu-Qing Zhang
  • Chong-Yi Su
  • Jian-Tao Song
  • Chong Meng
  • Dong-Xing Liu
Original Paper

Abstract

T-box2 (TBX2) expression has been reported to be related to aggressive tumor features. However, the role of TBX2 in non-small-cell lung cancer (NSCLC) tumorigenesis has never been elucidated. So we aimed at investigating the potential role of TBX2 in NSCLC. TBX2 expression was evaluated by qRT-PCR and Western blotting in 50 paired fresh lung cancer tissues as well as immunohistochemistry on 212 paraffin-embedded sections. We showed that the expression level of TBX2 was significantly increased in NSCLC as compared with the adjacent noncancerous tissue. Positive expression level of TBX2 was associated with histological type, lymph node metastasis and distant metastasis. Kaplan–Meier survival curves showed that positive expression level of TBX2 was associated with poor overall survival (OS) and progression-free survival of NSCLC patients. Results showed that TBX2 positivity was an independent prognostic factor for OS (HR 1.87, 95 % CI 1.004–3.153, p = 0.012). On the basis of these results, we suggested that TBX2 protein expression may be an unfavorable independent prognostic parameter for NSCLC.

Keywords

Non-small cell lung cancer TBX2 Prognosis 

Notes

Acknowledgments

This work was supported by a grant from the development project of medical science and technology of Shandong Province (2013WS0107).

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Bo Hu
    • 1
  • Hai-Ping Mu
    • 2
  • Yu-Qing Zhang
    • 2
  • Chong-Yi Su
    • 1
  • Jian-Tao Song
    • 1
  • Chong Meng
    • 1
  • Dong-Xing Liu
    • 1
  1. 1.Emergency DepartmentShandong Provincial Hospital Affiliated to Shandong UniversityJinanChina
  2. 2.The People’s Hospital of Huai YinJinanChina

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