MT1-MMP expression in the odontogenic region of rat incisors undergoing interrupted eruption

  • Nádia Fayez Omar
  • José Rosa Gomes
  • Juliana dos Santos Neves
  • Cristiane Ribeiro Salmon
  • Pedro Duarte Novaes
Original paper


MT1-MMP (membrane type matrix metalloproteinase-1) has been considered an important membrane-type matrix metalloproteinase involved in the remodeling process in tissue and organ development, including the processes of the tooth and root growth and dental eruption. Therefore, the aims of this study were to evaluate MT1-MMP expression in the odontogenic region, as well as the eruption rate and morphology of the lower-left rat incisor, where the eruption process was interrupted for 14 days by a steel wire attached from the center of the incisor labial face and braced to the first molar. In the interrupted eruption group, the eruption rate was significantly reduced, producing drastic morphological alterations in the tooth germ and socket area. The MT1-MMP expression was widespread in the dental follicle, in both groups studied (normal and interrupted eruption groups); however a significant decrease in immunostaining was observed in the interrupted eruption group. Results indicate that MT1-MMP may have an important role in the process of dental eruption.


Matrix metalloproteinase Eruption Incisor rat Periodontal ligament 



We are grateful to Eliene A. O. Narvaes of Immunohistochemical Laboratory of the UNICAMP, for expert technical assistance. The study was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq—Brazil.


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Nádia Fayez Omar
    • 1
  • José Rosa Gomes
    • 2
  • Juliana dos Santos Neves
    • 1
  • Cristiane Ribeiro Salmon
    • 3
  • Pedro Duarte Novaes
    • 1
  1. 1.Department of Morphology, Faculty Odontology of PiracicabaState University of Campinas, UNICAMPPiracicabaBrazil
  2. 2.Department of Structural Biology, Molecular and GeneticsUEPGPonta GrossaBrazil
  3. 3.Department of Prosthodontics and PeriodonticsFaculty Odontology of Piracicaba, State University of Campinas, UNICAMPPiracicabaBrazil

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