Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors

  • Jean Nunes dos Santos
  • Gabriel Queiroz Vasconcelos Oliveira
  • Clarissa Araújo Silva Gurgel
  • Renata Oliveira de Souza
  • Caroline Brandi Schlaepfer Sales
  • Alberto de Aguiar Pires Valença Neto
  • Eduardo Antônio Gonçalves Ramos
Original Paper


Keratocystic odontogenic tumor (KOT) is a benign cystic tumor that affects the jaw bones and may be associated with the nevoid basal cell carcinoma syndrome (NBCCS). Twenty-five cases diagnosed as KOT, including primary and recurrent tumors and those associated with NBCCS, were submitted to immunohistochemical study for analysis of cytokeratins (CKs) 7, 8, 10, 13, 14, 18 and 19. The results showed CK13 immunostained on the intermediate layers and upper cells. CK14 was expressed in all epithelial layers and in those areas where inflammation and subepithelial splits were present; this protein was preserved within the basal cells. CK 18 was expressed mainly in the basal layer, whereas CK19 was expressed mainly on the intermediate and superficial layers. The remaining CKs tested were not immuoreactive. The status of maturation of cytokeratin seems to be altered on KOTs, and this is not distinct when different tumors are compared.


Cytokeratin Odontogenic Keratocysts Odontogenic Neoplasms Immunohistochemistry 



This work was supported by the FAPESB (The State of Bahia Research) Grants n. 122/07.


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Jean Nunes dos Santos
    • 1
    • 4
  • Gabriel Queiroz Vasconcelos Oliveira
    • 1
  • Clarissa Araújo Silva Gurgel
    • 2
  • Renata Oliveira de Souza
    • 1
  • Caroline Brandi Schlaepfer Sales
    • 1
  • Alberto de Aguiar Pires Valença Neto
    • 3
  • Eduardo Antônio Gonçalves Ramos
    • 2
  1. 1.Department of Oral Pathology, Laboratory of Oral Surgical Pathology, School of DentistryFederal University of BahiaSalvadorBrazil
  2. 2.Laboratory of Pathology and Molecular BiologyGonçalo Moniz Research Center, Oswaldo Cruz FoundationSalvadorBrazil
  3. 3.Laser Center, School of DentistryFederal University of BahiaSalvadorBrazil
  4. 4.Faculdade de Odontologia-UFBASalvadorBrazil

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