Journal of Molecular Histology

, Volume 37, Issue 5–7, pp 219–223 | Cite as

The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer

  • Michael Zeidler
  • Celina G. Kleer
Original Paper


The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to tumorigenesis in multiple organs. In this review we summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis.


EZH2 Breast cancer DNA repair Homologous recombination Biomarker Prognosis Polycomb RAD51 RAD51 paralogs RAD51L1 


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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  1. 1.Department of Pathology and Comprehensive Cancer CenterUniversity of MichiganAnn ArborUSA

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