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Journal of Molecular Histology

, Volume 37, Issue 1–2, pp 5–7 | Cite as

Expression of Bcl-2 and Bax protein in normal pineal gland in children and young adult

  • Wiesław Marcol
  • Katarzyna Kotulska
  • Magdalena Larysz-Brysz
  • Izabela Malinowska-Kołodziej
  • Marek Mandera
  • Joanna Lewin-Kowalik
Short communication

Summary

The Bcl family contains both pro and antiapoptotic proteins participating in the regulation of neuronal cell death in several pathological conditions. However, very little is known about physiological profiles of Bcl-2/Bax expression in normal brain. In this study, we examined expression profile of Bcl-2 and Bax proteins in normal pineal gland in children. The material for analysis was obtained by biopsy of pineal parenchyma during surgery of pineal cysts. All specimens were labeled immunohistochemically and analyzed by means of confocal laser scanning microscope. We found only few Bcl-2 expressing (0.7%) and no Bax-immunopositive (0.0%) pinealocytes. Bcl-2-positive cells were mature neurons, neither young ones nor glia.

Keywords

Pineal Gland Pineal Region Pineal Region Tumor Pineal Cyst Pineal Parenchyma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Wiesław Marcol
    • 1
    • 2
  • Katarzyna Kotulska
    • 1
    • 3
  • Magdalena Larysz-Brysz
    • 1
  • Izabela Malinowska-Kołodziej
    • 1
  • Marek Mandera
    • 2
  • Joanna Lewin-Kowalik
    • 1
  1. 1.Department of PhysiologyMedical University of SilesiaKatowicePoland
  2. 2.Division of Pediatric Neurosurgery, Department of Pediatric SurgeryMedical University of SilesiaKatowicePoland
  3. 3.Department of Neurology and EpileptologyChildren’s Memorial HospitalWarsawPoland

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