Straightforward synthesis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O43 strain

Abstract

A concise synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O43 strain involving stereoselective β-D-mannosylation and α-L-fucosylation using corresponding trichloroacetimidate intermediates and perchloric acid supported over silica (HClO4-SiO2) as glycosylation promoter. The yield and stereoselectivity of the glycosylations were very good.

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Acknowledgements

P. S. thanks CSIR, New Delhi for providing Senior Research Fellowship. The work is supported by SERB, India (Project No. CRG/2019/000352 dated 23.01.2020) (AKM) and Bose Institute.

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Correspondence to Anup Kumar Misra.

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Shit, P., Misra, A.K. Straightforward synthesis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O43 strain. Glycoconj J (2020). https://doi.org/10.1007/s10719-020-09933-z

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Keywords

  • Oligosaccharide
  • Glycosylation
  • O-antigen
  • Diarrhea
  • E. coli