Glycoconjugate Journal

, Volume 30, Issue 8, pp 759–768 | Cite as

Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice

  • Ananya Chatterjee
  • Somanjana Khatua
  • Sirshendu Chatterjee
  • Shatavisa Mukherjee
  • Atashi Mukherjee
  • Soumitra Paloi
  • Krishnendu Acharya
  • Sandip K. Bandyopadhyay


The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model. Gastric tissue histology, myeloperoxidase (MPO) activity, cyclooxygenases (COX) 1 and 2 expression, prostaglandin E2 (PGE2) synthesis, and modulation of pro/anti inflammatory cytokines expression were studied for this purpose. Histological study shows that TEps (20 mg/kg) effectively healed the gastric ulceration. Based on biochemical results, the healing capacities of TEps could be attributed to reduction of MPO activity and protection of mucosal mucin content. Enhanced synthesis of PGE2 by modulation of COX-1 and COX-2 expression and a prominent shift of cytokines expression from pro (TNF-α, IL-1ß) to anti inflammatory (IL-10) side are also held responsible for ulcer healing. The preliminary study highlights the anti-ulcerogenic property of polysaccharide-rich fraction of Termitomyces eurhizus and opens an alternative cure for NSAID induced gastroduodenal diseases.


Gastric ulcer Mushroom NSAIDs Polysaccharide Termitomyces eurhizus 



Authors like to acknowledge Director, I.P.G.M.E&R, Kol-20 and Director, KPCMC&H, Kol-32 for their kind support and help. Ananya Chatterjee is thankful to Board of Research in Nuclear Science (BRNS), Department of Atomic Energy (DAE), GOI India for providing fellowship. The work was financially supported by BRNS, DAE, GOI.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Ananya Chatterjee
    • 1
    • 2
    • 3
  • Somanjana Khatua
    • 3
  • Sirshendu Chatterjee
    • 1
  • Shatavisa Mukherjee
    • 1
  • Atashi Mukherjee
    • 1
  • Soumitra Paloi
    • 3
  • Krishnendu Acharya
    • 3
  • Sandip K. Bandyopadhyay
    • 1
    • 2
  1. 1.Central Research Laboratory, Department of BiochemistryKPC Medical College and HospitalKolkataIndia
  2. 2.Research Wing, Department of BiochemistryUniversity College of Medicine, I.P.G.M.E&RKolkataIndia
  3. 3.Molecular and Applied Mycology and Plant Pathology Laboratory, Department of BotanyUniversity of CalcuttaKolkataIndia

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