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Glycoconjugate Journal

, Volume 30, Issue 3, pp 269–279 | Cite as

Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)-related lectins

  • Lei Wu
  • Jin-ku Bao
Article

Abstract

Galanthus nivalis agglutinin (GNA)-related lectin family, a superfamily of strictly mannose-binding specific lectins widespread among monocotyledonous plants, is well-known to possess a broad range of biological functions such as anti-tumor, anti-viral and anti-fungal activities. Herein, we mainly focused on exploring the precise molecular mechanisms by which GNA-related lectins induce cancer cell apoptotic and autophagic death targeting mitochondria-mediated ROS-p38-p53 apoptotic or autophagic pathway, Ras-Raf and PI3K-Akt anti-apoptotic or anti-autophagic pathways. In addition, we further discussed the molecular mechanisms of GNA-related lectins exerting anti-viral activities by blocking the entry of the virus into its target cells, preventing transmission of the virus as well as forcing virus to delete glycan in its envelope protein and triggering neutralizing antibody. In conclusion, these findings may provide a new perspective of GNA-related lectins as potential drugs for cancer and virus therapeutics in the future.

Keywords

GNA-related lectins Anti-tumor Anti-viral Drugs 

Abbreviations

CBAs

Carbohydrate binding agents

Con A

Concanavalin A

CV-N

Cyanovirin-N

DC-SIGN

Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin

EGFR

Epidermal growth factor receptor

ERK

Extracellular signal-regulated kinase

FADD

Fas-associated protein with death domain

GNA

Galanthus nivalis agglutinin

GRFT

Griffithsin

HHA

Hippeastrum hybrid agglutinin

LNL

Liparis noversa lectin

MEK

Mitogen-activated protein kinase

MMP

Mitochondrial membrane potential

mTOR

Mammalian target of rapamycin

MVL

Microcystis viridis lectin

NF–κB

Nuclear factor–κB

OJL

Ophiopogon japonicus lectin

PCD

Programmed cell death

PCL

Polygonatum cyrtonema lectin

PI3K

Phosphatidylinositol 3 kinase

POL

Polygonatum odoratum lectin

ROS

Reactive oxygen species

SVN

Scytovirin

SFL

Sophora flavescens lectin

TDL

Typhonium divaricatum lectin

TNF-α

Tumor necrosis factor-α

UDA

Urtica dioica agglutinin

Notes

Acknowledgments

We are grateful to Chun yang Li, Bo Liu, Huai long Xu (Sichuan University) for their critical reviews on this manuscript. This work was supported in part by National Natural Science Foundation of China (No. 30970643, No. 81173093 and No. J1103518).

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.School of Life Sciences and Key Laboratory of Bio-resources and Eco-environmentSichuan University, Ministry of EducationChengduChina

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