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Genetica

, Volume 123, Issue 1–2, pp 25–37 | Cite as

QTL mapping and the genetic basis of adaptation: recent developments

  • Zhao-Bang Zeng
Article

Abstract

Quantitative trait loci (QTL) mapping has been used in a number of evolutionary studies to study the genetic basis of adaptation by mapping individual QTL that explain the differences between differentiated populations and also estimating their effects and interaction in the mapping population. This analysis can provide clues about the evolutionary history of populations and causes of the population differentiation. QTL mapping analysis methods and associated computer programs provide us tools for such an inference on the genetic basis and architecture of quantitative trait variation in a mapping population. Current methods have the capability to separate and localize multiple QTL and estimate their effects and interaction on a quantitative trait. More recent methods have been targeted to provide a comprehensive inference on the overall genetic architecture of multiple traits in a number of environments. This development is important for evolutionary studies on the genetic basis of multiple trait variation, genotype by environment interaction, host–parasite interaction, and also microarray gene expression QTL analysis.

Keywords

genetic architecture genetic basis of adaptation genetic correlation genotype by environment interaction microarrays QTL mapping quantitative trait loci 

Abbreviations

CIM

composite interval mapping

EM

expectation and maximization algorithm

IM

interval mapping

MIM

multiple interval mapping

QTL

quantitative trait loci

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Copyright information

© Springer 2005

Authors and Affiliations

  1. 1.Departments of Statistics and Genetics & Bioinformatics Research CenterNorth Carolina State UniversityRaleighUSA

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