, Volume 79, Issue 2, pp 137–153 | Cite as

MAUP sensitivity analysis of ecological bias in health studies



Ecological bias introduced by spatial data aggregation causes significant variation in correlation statistics between pathogen exposures and illness rates. Modifiable areal unit problem sensitivity analysis is introduced to investigate the impact of spatial aggregation on ecological bias. Simulation produces numerical estimates for the relative magnitudes of components that effect ecological bias: (1) spatial autocorrelation of exposure concentrations; (2) scaling; (3) zoning; (4) network-clustered structure of illness events; (5) clustering of exposure measurements; and (6) the statistical distribution of exposure concentrations. These six components are mixed and used to compare random illness patterns to patterns determined from a dose–response model. Of the six, spatial autocorrelation of exposure data has the greatest influence on ecological bias. Spatial aggregation can cause high correlations in random illness patterns. More importantly, if pathogen concentrations are randomly distributed in space, then there is a greater likelihood that data aggregation might obscure a strong association.


GIS Aggregation MAUP Bias 



This research was funded by EPA grant number R831629.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of GeographyUniversity of CincinnatiCincinnatiUSA
  2. 2.School of Geography and PlanningSun Yat-sen UniversityGuangzhouPeople’s Republic of China
  3. 3.School of EnergyEnvironmental, Biological and Medical Engineering, University of CincinnatiCincinnatiUSA

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