Familial Cancer

, Volume 18, Issue 3, pp 363–367 | Cite as

Hereditary gastric cancer: what’s new? Update 2013–2018

  • Rachel S. van der Post
  • Carla Oliveira
  • Parry Guilford
  • Fátima CarneiroEmail author


Around 10–20% of gastric cancer patients have relatives with a diagnosis of GC and in 1–3% of patients a genetic cause can be confirmed. Histopathologically, GC is classified into intestinal-type, with glandular growth, and diffuse-type with poorly cohesive growth pattern often with signet ring cells. Familial or hereditary GC is classified into hereditary diffuse GC (HDGC), familial intestinal GC (FIGC) and polyposis forms. This review focuses on recent research findings and new concepts of hereditary GC.


Hereditary diffuse gastric cancer E-Cadherin Stomach 



  1. 1.
    van der Post RS, Vogelaar IP, Carneiro F et al (2015) Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. J Med Genet 52:361–374CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Bosman FT, Carneiro F, Hruban RH et al (2012) WHO classification of tumours of the digestive system, 4th edition. IARC Scientific Publications, LyonGoogle Scholar
  3. 3.
    Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64:31–49CrossRefGoogle Scholar
  4. 4.
    Oliveira C, Pinheiro H, Figueiredo J et al (2015) Familial gastric cancer: genetic susceptibility, pathology, and implications for management. Lancet Oncol 16:e60–e70CrossRefGoogle Scholar
  5. 5.
    Guilford P, Hopkins J, Harraway J et al (1998) E-cadherin germline mutations in familial gastric cancer. Nature 392:402–405CrossRefGoogle Scholar
  6. 6.
    Hansford S, Kaurah P, Li-Chang H et al (2015) Hereditary diffuse gastric cancer syndrome: CDH1 mutations and beyond. JAMA Oncol 1:23–32CrossRefGoogle Scholar
  7. 7.
    Caldas C, Carneiro F, Lynch HT et al (1999) Familial gastric cancer: overview and guidelines for management. J Med Genet 36:873–880PubMedPubMedCentralGoogle Scholar
  8. 8.
    Worthley DL, Phillips KD, Wayte N et al (2012) Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. Gut 61:774–779CrossRefPubMedGoogle Scholar
  9. 9.
    Li J, Woods SL, Healey S et al (2016) Point mutations in exon 1B of APC reveal gastric adenocarcinoma and proximal polyposis of the stomach as a familial adenomatous polyposis variant. Am J Hum Genet 98:830–842CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    van der Post RS, Gullo I, Oliveira C et al (2016) Histopathological, molecular, and genetic profile of hereditary diffuse gastric cancer: current knowledge and challenges for the future. Adv Exp Med Biol 908:371–391CrossRefGoogle Scholar
  11. 11.
    Rocha JP, Gullo I, Wen X et al (2018) Pathological features of total gastrectomy specimens from asymptomatic hereditary diffuse gastric cancer patients and implications for clinical management. Histopathology 73:878–886CrossRefGoogle Scholar
  12. 12.
    van der Post RS, van Dieren J, Grelack A et al (2018) Outcomes of screening gastroscopy in first-degree relatives of patients fulfilling hereditary diffuse gastric cancer criteria. Gastrointest Endosc 87:397–404.e2CrossRefPubMedGoogle Scholar
  13. 13.
    Mi EZ, Mi EZ, di Pietro M et al (2018) A comparative study of endoscopic surveillance in hereditary diffuse gastric cancer according to CDH1 mutation status. Gastrointest Endosc 87:408–418CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    van der Post RS, Vogelaar IP, Manders P et al (2015) Accuracy of hereditary diffuse gastric cancer testing criteria and outcomes in patients with a germline mutation in CDH1. Gastroenterology 149:897–906.e19CrossRefGoogle Scholar
  15. 15.
    Benusiglio PR, Malka D, Rouleau E et al (2013) CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study. J Med Genet 50:486–489CrossRefPubMedGoogle Scholar
  16. 16.
    Oliveira C, Senz J, Kaurah P et al (2009) Germline CDH1 deletions in hereditary diffuse gastric cancer families. Hum Mol Genet 18:1545–1555CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Hakkaart C, Ellison-Loschmann L, Day R et al (2019) Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand Maori. Fam Cancer 18:83–90CrossRefPubMedGoogle Scholar
  18. 18.
    Yamada M, Fukagawa T, Nakajima T et al (2014) Hereditary diffuse gastric cancer in a Japanese family with a large deletion involving CDH1. Gastric Cancer 17:750–756CrossRefGoogle Scholar
  19. 19.
    Sugimoto S, Yamada H, Takahashi M et al (2014) Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. Gastric Cancer 17:745–749CrossRefGoogle Scholar
  20. 20.
    Melo S, Figueiredo J, Fernandes MS et al (2017) Predicting the functional impact of CDH1 missense mutations in hereditary diffuse gastric cancer. Int J Mol Sci 18:E2687CrossRefPubMedGoogle Scholar
  21. 21.
    Lee K, Krempely K, Roberts ME et al (2018) Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline CDH1 sequence variants. Hum Mutat 39:1553–1568CrossRefPubMedGoogle Scholar
  22. 22.
    Pinheiro H, Bordeira-Carrico R, Seixas S et al (2010) Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. Hum Mol Genet 19:943–952CrossRefPubMedGoogle Scholar
  23. 23.
    Grady WM, Willis J, Guilford PJ et al (2000) Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nat Genet 26:16–17CrossRefPubMedGoogle Scholar
  24. 24.
    Oliveira C, Sousa S, Pinheiro H et al (2009) Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology 136:2137–2148CrossRefPubMedGoogle Scholar
  25. 25.
    Sahasrabudhe R, Lott P, Bohorquez M et al (2017) Germline mutations in PALB2, BRCA1, and RAD51C, which regulate DNA recombination repair, in patients with gastric cancer. Gastroenterology 152:983–986CrossRefGoogle Scholar
  26. 26.
    Vogelaar IP, van der Post RS, van Krieken JHJ et al (2017) Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing. Eur J Hum Genet 25:1246–1252CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Slavin T, Neuhausen SL, Rybak C et al (2017) Genetic gastric cancer susceptibility in the international clinical cancer genomics community research network. Cancer Genet 216–217:111–119CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Majewski IJ, Kluijt I, Cats A et al (2013) An alpha-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. J Pathol 229:621–629CrossRefGoogle Scholar
  29. 29.
    Weren RDA, van der Post RS, Vogelaar IP et al (2018) Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility. J Med Genet 55:669–674CrossRefGoogle Scholar
  30. 30.
    Koslov ER, Maupin P, Pradhan D et al (1997) Alpha-catenin can form asymmetric homodimeric complexes and/or heterodimeric complexes with beta-catenin. J Biol Chem 272:27301–27306CrossRefPubMedGoogle Scholar
  31. 31.
    Fewings E, Larionov A, Redman J et al (2018) Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study. Lancet Gastroenterol Hepatol 3:489–498CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Yap AS, Gomez GA, Parton RG (2015) Adherens junctions revisualized: organizing cadherins as nanoassemblies. Dev Cell 35:12–20CrossRefGoogle Scholar
  33. 33.
    Papadopulos A (2017) Membrane shaping by actin and myosin during regulated exocytosis. Mol Cell Neurosci 84:93–99CrossRefGoogle Scholar
  34. 34.
    Diz-Munoz A, Fletcher DA, Weiner OD (2013) Use the force: membrane tension as an organizer of cell shape and motility. Trends Cell Biol 23:47–53CrossRefGoogle Scholar
  35. 35.
    Head BP, Patel HH, Insel PA (2014) Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochim Biophys Acta 1838:532–545CrossRefGoogle Scholar
  36. 36.
    Chen A, Beetham H, Black MA et al (2014) E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition. BMC Cancer 14:552CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Godwin TD, Kelly ST, Brew TP et al (2019) E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function. Gastric Cancer 22:273–286CrossRefPubMedGoogle Scholar
  38. 38.
    Choi YJ, Kim N (2016) Gastric cancer and family history. Korean J Intern Med 31:1042–1053CrossRefPubMedPubMedCentralGoogle Scholar
  39. 39.
    Vogelaar IP, van der Post RS, van de Vosse E et al (2015) Gastric cancer in three relatives of a patient with a biallelic IL12RB1 mutation. Fam Cancer 14:89–94CrossRefPubMedGoogle Scholar
  40. 40.
    Syngal S, Brand RE, Church JM et al (2015) ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol 110:223–262; quiz 263CrossRefPubMedPubMedCentralGoogle Scholar
  41. 41.
    van der Post RS, Carneiro F (2017) Emerging concepts in gastric neoplasia: heritable gastric cancers and polyposis disorders. Surg Pathol Clin 10:931–945CrossRefPubMedGoogle Scholar
  42. 42.
    Repak R, Kohoutova D, Podhola M et al (2016) The first European family with gastric adenocarcinoma and proximal polyposis of the stomach: case report and review of the literature. Gastrointest Endosc 84:718–725CrossRefPubMedGoogle Scholar
  43. 43.
    Yanaru-Fujisawa R, Nakamura S, Moriyama T et al (2012) Familial fundic gland polyposis with gastric cancer. Gut 61:1103–1104CrossRefPubMedGoogle Scholar
  44. 44.
    Beer A, Streubel B, Asari R et al (2017) Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS)—a rare recently described gastric polyposis syndrome - report of a case. Z Gastroenterol 55:1131–1134CrossRefPubMedGoogle Scholar
  45. 45.
    Mitsui Y, Yokoyama R, Fujimoto S et al (2018) First report of an Asian family with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) revealed with the germline mutation of the APC exon 1B promoter region. Gastric Cancer 21:1058–1063CrossRefPubMedGoogle Scholar
  46. 46.
    de Boer WB, Ee H, Kumarasinghe MP (2018) Neoplastic lesions of gastric adenocarcinoma and proximal polyposis syndrome (GAPPS) are gastric phenotype. Am J Surg Pathol 42:1–8PubMedGoogle Scholar
  47. 47.
    Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Rachel S. van der Post
    • 1
  • Carla Oliveira
    • 2
    • 3
    • 4
  • Parry Guilford
    • 5
  • Fátima Carneiro
    • 2
    • 3
    • 4
    Email author
  1. 1.Department of PathologyRadboud university medical centreNijmegenThe Netherlands
  2. 2.i3S - Instituto de Investigação e Inovação em SaúdeUniversity of PortoPortoPortugal
  3. 3.Ipatimup - Institute of Molecular Pathology and ImmunologyUniversity of PortoPortoPortugal
  4. 4.Faculty of MedicineUniversity of PortoPortoPortugal
  5. 5.Cancer Genetics Laboratory, Department of Biochemistry, Centre for Translational Cancer Research, Te Aho MatatūUniversity of OtagoDunedinNew Zealand

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