Abstract
Familial adenomatous polyposis patients often present with non-malignant extra-intestinal manifestations which include dental anomalies that may be evident prior to the appearance of the colonic adenomas. The aims of this study were to describe the prevalence and type of dental anomalies and the relationships between gene mutations and dental anomalies in these patients. Twenty-two pediatric familial adenomatous polyposis patients and 46 controls, who were age and gender matched participated. Familial adenomatous polyposis patient’s had a dental examination with panoramic radiograph and medical record review for age at diagnosis, the presence of the adenomatous polyposis coli gene mutation, and determination of other extra-intestinal manifestations on the body. The control group was identified from a retrospective chart review and selected if there was a current panoramic radiograph. The only significant difference between familial adenomatous polyposis patients and controls were the presence of jaw osteomas and sclerosis (p = .0001). Patients with a mutation in, or upstream of codon 1309 had a higher frequency of osteomas (77.8%) and jaw-bone sclerosis (44.4%), and 77% of these had at least one dental anomaly. This preliminary study showed an association between a genetic variant at, or upstream of codon 1309, and radiographic dental anomalies.
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Acknowledgements
We would like to acknowledge Shawna Ricks MSN, RN, CCRC for her invaluable help with the coordination and execution of this project. We would also like to acknowledge Dr. Jesse Gardner, Dr. Dirk Eckroat and Dr. Kelly Jobe who assisted in data collection.
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All procedures performed in studies involving human participants were in accordance with ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Septer, S., Bohaty, B., Onikul, R. et al. Dental anomalies in pediatric patients with familial adenomatous polyposis. Familial Cancer 17, 229–234 (2018). https://doi.org/10.1007/s10689-017-0035-5
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DOI: https://doi.org/10.1007/s10689-017-0035-5