Occurrence of renal cell carcinoma and hematologic malignancies (predominantly lymphoid) in individuals and in families
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The relationship between renal cell cancer (RCC) and hematologic malignancy (HM) in the same individual has been reported for more than 20 years, and is noted in SEER database studies. Family histories suggest a familial association as well. This study evaluates the occurrence of renal cell cancer and hematologic malignancies in individual patients and families, and the occurrence of age-of-onset anticipation among generations. Family history data from our familial patient registry, including more than 700 pedigrees of familial hematologic malignancies, and 700 patients with renal cell cancer, were reviewed. Twenty-six patients with a personal history of both RCC and HM are reported. Seventy four patients with RCC are noted to have 95 family members with HM. Consistent with past reports, there was male predominance among the patients with both diseases (71 %), and among the RCC patients’ relatives with HM (57 %). Also consistent was a predominance of lymphoid malignancies in those with both diseases (92 %) and in the HMs among family members of RCC patients (79 %). The majority (95 %) of HM relatives were first or second degree relatives of the patient with RCC. Thirty of 34 parent/child pairs demonstrated age of onset anticipation in which the child developed either disease at a younger age than the parent. The co-occurrence of RCC and HM in the same patient has been shown to be significantly greater than expected. Families also appear to have an increased association. The appearance of anticipation suggests that genetic factors may be significant in this association of RCC and HM.
KeywordsRenal cell cancer Familial hematologic malignancies Lymphoma
Supported in part by Cancer Research Foundation of New York, Chappaqua NY; Children’s Leukemia Research Association, Garden City, New York; Long Island League Against Cancer (L.I.L.A.C.), New York; Jewish Community Trust, New York.
All authors have contributed to this manuscript, by collection and assembly of data, data analysis and interpretation, manuscript writing and final approval of the manuscript. In addition, Drs Wiernik and Dutcher have provided study conception and design and have contributed subjects for the study.
Compliance with ethical standards
Conflict of interest
Drs. Varella and Chintapatla have no conflicts to disclose. Dr. Wiernik participates in speakers bureau and advisory boards for Novartis and Celgene. Dr. Dutcher participates in speakers bureau and advisory boards for Prometheus, Novartis and Pfizer, and is a member of data safety and monitoring boards for Bristol-Myers-Squibb, Tracon, and PrECOG.
The study protocol was approved by the institutional review board. All participants gave informed consent. All procedures performed were in accordance with ethical standards of the institution and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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