Familial Cancer

, Volume 15, Issue 3, pp 357–358 | Cite as

Introduction to special issue of Familial Cancer

  • Henry T. Lynch
  • Carrie L. Snyder

On September 17–18, 2015, a distinguished group of international experts presented papers at a symposium sponsored by Creighton University, Omaha, Nebraska, in honor of the career of Henry T. Lynch, M.D. This special issue of Familial Cancer is composed of those papers. A common theme is the progress made over the years in the diagnosis and management of hereditary cancer.

For centuries, families and physicians have observed familial clustering of cancer, often manifesting striking phenotypes [1, 2, 3, 4]. The work of Gregor Mendel in 1866 [5] led to suggestions of a hereditary etiology of such phenomena. That same year, Paul Broca [6] published an account of his wife’s family through five generations noting an excess of cancers of the breast and gastrointestinal tract, postulating an inheritance of cancer susceptibility. About two decades later, accounts of familial polyposis coli (now called familial adenomatous polyposis) were described with possible genetic origin [7, 8, 9]. The...


Germline Mutation Familial Adenomatous Polyposis Lynch Syndrome Retinoblastoma Cancer Susceptibility 
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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  1. 1.OmahaUSA

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