Familial Cancer

, Volume 10, Issue 2, pp 391–396 | Cite as

Familial gastric cancer: update for practice management

  • Giovanni Corso
  • Daniele Marrelli
  • Franco Roviello


About 90% of gastric carcinoma presents a sporadic setting and only 10% shows a familial cluster; among this group, 1–3% are considered as hereditary syndromes, with a clear genetic pathway. The most important genetic mechanisms are associated with CDH1 germline mutations, causing the hereditary diffuse gastric cancer syndrome. Other inherited predispositions with gastric carcinoma are the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz-Jeghers syndromes. In this brief update, we described these principal hereditary syndromes offering a simple management to physicians where are these diseases diagnosed.


E-cadherin Mismatch repair genes TP53 STK11 



This work was supported by Istituto Toscano Tumori (‘‘Gene expression profile and therapeutic implication in gastric cancer. From the clinical overview to the translational research’’; Grant ITT-2007) and PhD grant (ref. SFRH/BD/40090/2007).

Conflict of interest

The author(s) declare that they have no competing interests.


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Giovanni Corso
    • 1
    • 2
    • 3
  • Daniele Marrelli
    • 1
    • 2
  • Franco Roviello
    • 1
    • 2
  1. 1.Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research LaboratoryUniversity of SienaSienaItaly
  2. 2.Istituto Toscano Tumori (ITT)FlorenceItaly
  3. 3.Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)PortoPortugal

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