Familial Cancer

, Volume 9, Issue 4, pp 661–662 | Cite as

Hereditary predisposition rather than environmental factor are likely to explain the familial link between uveal melanoma and other cancers

  • M. H. Abdel-Rahman
  • R. Pilarski


Retinal Pigment Epithelial Cell Uveal Melanoma Family Cancer History Shared Environmental Factor Hereditary Predisposition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Grant WB, Moan JE, Micu E, Porojnicu AC, Juzeniene A (2010) Similarities in solar ultraviolet irradiance and other environmental factors may explain much of the family link between uveal melanoma and other cancers. Fam Cancer. doi: 10.1007/s10689-010-9374-1
  2. 2.
    Abdel-Rahman MH, Pilarski R, Ezzat S, Sexton J, Davidorf FH (2010) Cancer family history characterization in an unselected cohort of 121 patients with uveal melanoma. Fam Cancer 9(3):431–438CrossRefPubMedGoogle Scholar
  3. 3.
    Moan J, Cicarma E, Setlow R, Porojnicu AC, Grant WB, Juzeniene A (2010) Time trends and latitude dependence of uveal and cutaneous malignant melanoma induced by solar radiation. Dermatoendocrinol 2(1):3–8CrossRefGoogle Scholar
  4. 4.
    IARC (2008) Vitamin D and cancer. IARC Working Group Reports, vol 5. International Agency for Research on Cancer, Lyon, 25 Nov 2008Google Scholar
  5. 5.
    Helzlsouer KJ (2010) Overview of the cohort consortium vitamin D pooling project of rarer cancers. Am J Epidemiol 172(1):4–9CrossRefPubMedGoogle Scholar
  6. 6.
    Singh AD, Rennie IG, Seregard S, Giblin M, McKenzie J (2004) Sunlight exposure, pathogenesis of uveal melanoma. Surv Ophthalmol 49(4):419–428CrossRefPubMedGoogle Scholar
  7. 7.
    Tucker MA (2009) Melanoma epidemiology. Hematol Oncol Clin North Am 23(3):383–395CrossRefPubMedGoogle Scholar
  8. 8.
    Nelson AA, Tsao H (2009) Melanoma and genetics. Clin Dermatol 27(1):46–52CrossRefPubMedGoogle Scholar
  9. 9.
    Hampel H, Sweet K, Westman JA, Offit K, Eng C (2004) Referral for cancer genetics consultation: a review, compilation of risk assessment criteria. J Med Genet 41(2):81–91CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Department of OphthalmologyThe Ohio State UniversityColumbusUSA
  2. 2.Clinical Cancer Genetics Program, Department of Internal Medicine and Comprehensive Cancer CenterThe Ohio State UniversityColumbusUSA

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