The Environmentalist

, Volume 32, Issue 2, pp 236–241 | Cite as

Magnetically treated water at 4 Hz and 2.5 mT as a modulator of cisplatin effect on cell hydration and ouabain binding of sarcoma-180 tissue

  • L. R. Yeganyan
  • R. E. Muradyan
  • F. H. Arsenyan
  • G. K. Bazikyan
  • S. N. Ayrapetyan


There are many data about the extremely low-frequency electromagnetic fields (ELF-EMF) therapeutic use, especially in the field of oncology. Recent data suggest that 4 Hz EMF having dehydration effect on tissues has a pronounced antitumor activity on sarcoma-180 in mice. It was shown that 4 Hz EMF have pronounced effects on physicochemical properties of water and water solution. Therefore, the aim of the present work was the comparative study of the modulation effect of ELF-EMF on cisplatin-induced changes cell hydration and number of ouabain receptors in membrane of sarcoma-180 tumor tissues. Tissue hydration was measured as wet weight/dry weight and expressed as a water content of g/g in dry weight. The number of 3H-ouabain receptors in membrane was counted by isotope scintillation counter. In conclusion, ELF-EMF can be a possible tool for stimulation of cisPt antitumor effect.


Electromagnetic fields Cancer Cisplatin 



We thank Anna Abrahamyan for help with English editing.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • L. R. Yeganyan
    • 1
  • R. E. Muradyan
    • 2
  • F. H. Arsenyan
    • 2
  • G. K. Bazikyan
    • 3
  • S. N. Ayrapetyan
    • 1
  1. 1.Life Sciences International Postgraduate Educational CenterYerevanArmenia
  2. 2.NAS RA the Scientific Technological Center of Organic and Pharmaceutical Chemistry SNPOYerevanArmenia
  3. 3.National Center of OncologyYerevanArmenia

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