Maternal nut intake in pregnancy and child neuropsychological development up to 8 years old: a population-based cohort study in Spain
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There is scientific evidence on the protective effects of nut intake against cognitive decline in the elderly; however, this effect has been less explored in child neurodevelopment and no studies have explored the potential longitudinal association with nut intake during pregnancy. We aimed to analyze the association of maternal nut intake during pregnancy with child neuropsychological outcomes. We included 2208 mother–child pairs from a population-based birth cohort in four regions of Spain. The follow up settings were during pregnancy (first and third trimesters), birth, 1.5, 5 and 8 years. Neuropsychological examinations were based on Bayley Scales of Infant Development (1.5 years), McCarthy scales of Children’s Abilities (5 year), Attention Network Test (ANT, 8 year) and N-Back test (8 year). Nut intake in pregnancy was reported through a validated food frequency questionnaire during the first and the third trimester. Multivariable regressions analyzed associations after controlling for priori selected confounders notably maternal education, social class, body mass index, energy intake, fish intake, omega-3 supplements, alcohol consumption and smoking habits during pregnancy. Children within the highest tertile of maternal nut consumption during first pregnancy trimester (> 32 g/week) had a decrease of 13.82 ms [95% confidence interval (CI) − 23.40, − 4.23] in the ANT—hit reaction time standard error, compared to the first tertile (median 0 g/w). A similar protective association pattern was observed with the other cognitive scores at the different child ages. After correcting for multiple testing using Bonferroni familywise error rate (FWER), Hochberg FWER and Simes false discovery rate, ANT—hit reaction time standard error remained significant. Final model estimates by inverse probability weighting did not change results. Third pregnancy trimester nut intake showed weaker associations. These data indicate that nut intake during early pregnancy is associated with long-term child neuropsychological development. Future cohort studies and randomized clinical trials are needed to confirm this association pattern in order to further extend nutrition guidelines among pregnant women.
KeywordsNut Maternal diet Children Neurodevelopment Population-based cohort
Attention Network Test
Brain-derived neurotrophic factor
Body mass index
Bayley Scales of Infant Development
Directed Acyclic Graph
Disability adjusted life-years
False discovery rate
Food frequency questionnaire
Familywise error rate
Hit reaction time standard error
Infancia y Medio Ambiente (Environment and Childhood)
Inverse probability weighting
McCarthy Scales of Children’s Abilities
Prevention with Mediterranean Diet
Polyunsaturated fatty acids
Relative Mediterranean diet score
We would like to thank all the participants of the INMA Project for their collaboration as well as the project investigators at each cohort center as well as the coordination centers. A full roster of the INMA Project investigator can be found at http://www.PROYECTOINMA.org/. We would like to thank also Nuria Sebastian-Galles and her team who have designed the N-Back and ANT tests.
DR, JS and JJ designed research. FG analyzed data, wrote the paper and is responsible for final content. CP, JJ, DR, SFB, RGE supported and revised the statistical analyses. JJ coordinated and supervised data collection. JJ and DR supervised the interpretation of the results. All authors critically reviewed the manuscript and approved the final version of the manuscript.
This study was funded by Grants from Spanish Institute of Health Carlos III-Ministry of Economy and Competitiveness (INMA Network G03/176, CB06/02/0041, and FIS-FEDER: PI03/1615, PI04/1436, PI08/1151, PI04/2018, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI06/0867, PI07/0314, PI09/02647, PS09/00090, PI09/02311, MS11/0178, PI13/1944, PI13/2032, PI13/02429, PI16/1288, and PI17/00663), Generalitat de Catalunya-CIRIT 1999SGR 00241, JCI-2011–09771–MICINN, Generalitat Valenciana (Conselleria de Sanitat-048/2010 and 060/2010 and FISABIO-UGP 15-230, 15-244, and 15-249), Alicia Koplowitz Foundation, Universidad de Oviedo, Fundación Cajastur-Liberbank, Department of Health of the Basque Government (2005111093 and 2009111069), the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001), and the Fundación Roger Torné. This study has been funded by Instituto de Salud Carlos III through the projects “CP14/00108 & PI16/00261” (Co-funded by European Regional Development Fund “A way to make Europe”). Jordi Julvez, Mònica Guxens and Maria-Jose Lopez-Espinosa hold a Miguel Servet contract (MS14/00108, MS13/00054 and MSII16/00051, respectively) awarded by the Spanish Institute of Health Carlos III (Ministry of Economy and Competitiveness). Funding sources played no role in the design and conduct of the study, including: collection, management, analysis and interpretation of the data; or the preparation, review, and approval of the manuscript. The authors would also like to acknowledge all the study participants for their generous collaboration, and the interviewers for their assistance in contacting the families and administering the questionnaires.
Compliance with ethical standards
Conflict of interest
The authors have indicated they have no potential conflicts of interest to disclose.
- 1.Gakidou E, Afshin A, Abajobir AA, et al. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1345–422.CrossRefGoogle Scholar
- 2.Eslamparast T, Sharafkhah M, Poustchi H, et al. Nut consumption and total and cause-specific mortality: results from the Golestan Cohort Study. Int J Epidemiol. 2016;46(1):75–85.Google Scholar
- 11.Nyaradi A, Li J, Hickling S, Foster J, Oddy WH. The role of nutrition in children’s neurocognitive development, from pregnancy through childhood. Front Hum Neurosci. 2013;7(97):1–16.Google Scholar
- 15.Vioque J, Gimenez-monzó D, García-de-la-hera M, Iñiguez C, Study IC. Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area. Nutr J. 2013;12(26):1–9.Google Scholar
- 16.US Department of Agriculture, Agricultural Research Service, Nutrient Data Laboratory. USDA National Nutrient Database for Standard Reference, Legacy. Version Current: April 2018. Internet:/nea/bhnrc/ndl.Google Scholar
- 23.González de Rivera JL, Derogatis L, de las Cuevas C. The Spanish version of the SCL-90-R: normative data in general population. Baltimore: Towson; 1989.Google Scholar
- 24.Weschler D, Kaufman A. WAIS-III. Escala de Inteligencia de Wechsler Para Adultos (III). Madrid: TEA Ediciones; 2001.Google Scholar
- 27.Spanish Ministry of Public Works. Atlas de La Vulnerabilidad Urbana En España 2001 Y 2011: Metodologia, Contenidos Y Créditos (Edicion de Diciembre de 2015); 2012.Google Scholar
- 29.Dapcich V, Salvador-Castell G, Ribas-Barba L, Pérez-Rodrigo C, Aranceta-Bartrina J, Serra-Majem L. Guía de la alimentación saludable. Spain: Sociedad Española de Nutrición Comunitaria; 2004.Google Scholar
- 31.Nielsen SJ, Kit BK, Ogden CL. Nut consumption among U.S. adults, 2009–2010. NCHS data brief, no 176. Hyattsville, MD: National Center for Health Statistics. 2014.Google Scholar
- 34.Martínez-Lapiscina EH, Clavero P, Toledo E, et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. Cognit Neurol. 2013;84:1318–25.Google Scholar
- 39.Greenberg JA, Bell SJ, Van Ausdal W. Omega-3 fatty acid supplementation during pregnancy. Rev Obstet Gynecol. 2008;1(4):162–9.Google Scholar
- 46.Suades-González E, Forns J, García-Esteban R, López-Vicente M, Esnaola M, Álvarez-Pedrerol M, Julvez J, Cáceres A, Basagaña X, López-Sala A, Sunyer J. A longitudinal study on attention development in primary school children with and without teacher-reported symptoms of ADHD. Front Psychol. 2017;8:655.CrossRefGoogle Scholar
- 49.Eslamparast T, Sharafkhah M, Poustchi H, et al. Nut consumption and total and cause-specific mortality: results from the Golestan Cohort Study. Int J Epidemiol. 2017;46(1):75–85.Google Scholar