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New cancer cases in France in 2015 attributable to infectious agents: a systematic review and meta-analysis

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Abstract

To provide an assessment of the burden of cancer in France in 2015 attributable to infectious agents. A systematic literature review in French representative cancer cases series was undertaken of the prevalence of infectious agents with the major associated cancer types. PubMed was searched for original studies published up to September 2016; random-effects meta-analyses were performed. Cancer incidence data were obtained from the French Cancer Registries Network, thereby allowing the calculation of national incidence estimates. The number of new cancer cases attributable to infectious agents was calculated using population-attributable fractions according to published methods. Of the 352,000 new cancer cases in France in 2015, 14,336 (4.1% of all new cancer cases) were attributable to infectious agents. The largest contributors were human papillomavirus (HPV) and Helicobacter pylori, responsible for 6333 and 4406 new cancer cases (1.8 and 1.3% of all new cancer cases) respectively. Infectious agents caused a non-negligible number of new cancer cases in France in 2015. Most of these cancers were preventable. The expansion of vaccination (i.e., for hepatitis B virus and HPV) and screen-and-treat programs (for HPV and hepatitis C virus, and possibly for H. pylori) could greatly reduce this cancer burden.

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Acknowledgements

The authors would like to thank D. Max Parkin, Lesley Rushton, and Jürgen Rehm, the Steering Committee of the project entitled “Définition des priorités pour la prévention du cancer en France métropolitaine: la fraction de cancers attribuables aux modes de vie et aux facteurs environnementaux.” The authors would also like to thank the French Cancer Registries Network (FRANCIM) and Dr. Alain Monnereau for providing cancer incidence data for France.

Funding

I. Soerjomataram has received funds from L’Institut National Du Cancer (Grant No. 2015-002) for the project: “Définition des priorités pour la prévention du cancer en France métropolitaine: la fraction de cancers attribuables aux modes de vie et aux facteurs environnementaux.” C. de Martel was funded by the Fondation de France (Grant No. 00039621).

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Authors and Affiliations

  1. Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France

    Kevin David Shield, Claire Marant Micallef, Jérôme Vignat, Freddie Bray & Isabelle Soerjomataram

  2. Infections and Cancer Epidemiology Group, International Agency for Research on Cancer, Lyon, France

    Catherine de Martel & Martyn Plummer

  3. Prevention and Implementation Group, International Agency for Research on Cancer, Lyon, France

    Isabelle Heard

  4. Hospital Tenon, AP-HP, Paris, France

    Isabelle Heard

  5. Laboratoire de Bactériologie, Hôpital Pellegrin, Bordeaux, France

    Francis Megraud

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Shield, K.D., Marant Micallef, C., de Martel, C. et al. New cancer cases in France in 2015 attributable to infectious agents: a systematic review and meta-analysis. Eur J Epidemiol 33, 263–274 (2018). https://doi.org/10.1007/s10654-017-0334-z

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