Meta-analysis of diagnostic performance studies
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When a busy clinician needs to search the literature to address a question, (s)he is commonly faced with the insurmountable task of ploughing through the ever-increasing number of scientific publications. Systematic reviews provide a quick and easy way for such a physician to answer questions in an efficient manner. Systematic reviews summarize and combine the published literature on a particular topic and are considered the top level on the evidence hierarchy. If the summarized data permits, results from the individual studies are combined in a meta-analysis which provides a quantitative pooled result. Such a pooled result is useful both in-of-itself and for comparative (cost-)effectiveness research using decision modeling. Such exercises are extremely useful given current prolific publication, both for the busy clinican and for the comparative (cost-)effectiveness researcher.
Inspite of the advantages of systematic reviews and meta-analyses, there are limitations of such analyses...
KeywordsDiagnostic Accuracy Diagnostic Performance Pool Result Multivariable Logistic Regression Analysis Severe Coronary Artery Disease
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