Gout and the risk of Parkinson’s disease in Denmark
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There is growing evidence that oxidative stress plays a major role in Parkinson’s disease (PD) etiology [1, 2]. Importantly, uric acid has been shown in experimental studies to have an antioxidant effect on neurons [3, 4]. Recently, several observational studies have also evaluated associations between serum uric acid levels and PD risk and have consistently reported a lower risk of PD among individuals with the highest levels of serum uric acid [5, 6, 7, 8, 9, 10]. The most common metabolic disorder underlying hyper uricemia is gout. Thus, if hyperuricemia decreases the risk of PD, gout should also be negatively associated with PD risk. Two studies, to date, have evaluated the association between gout and PD risk and both reported an inverse association [11, 12], although the association was only observed among men in one of the two studies .
Using Danish population registers, we aimed to confirm the findings from these two previous observational studies. We investigated whether a...
KeywordsChronic Obstructive Pulmonary Disease Uric Acid Gout Serum Uric Acid Hyperuricemia
This study was supported by a grant from the National Institutes of Environmental Health Sciences, USA (Grant No. R01 ES013717). Partial funding was also provided by the National Institutes of Neurologic Diseases and Stroke, USA for the UCLA Udall Parkinson Disease Center of Excellence Grant No. P50 NS038367). The funding source had no role in the design or analysis of the study or in the decision to submit the manuscript for publication.
- 2.Kyrozis A, Ghika A, Stathopoulos P, Vassilopoulos D, Trichopoulos D, Trichopoulou A. Dietary and lifestyle variables in relation to incidence of Parkinson’s disease in Greece. Eur J Epidemiol 2013. doi: 10.1007/s10654-012-9760-0.