European Journal of Epidemiology

, Volume 28, Issue 4, pp 359–360 | Cite as

Gout and the risk of Parkinson’s disease in Denmark

  • Eva Schernhammer
  • Jiaheng Qiu
  • Lene Wermuth
  • Christina Funch Lassen
  • Soren Friis
  • Beate Ritz
Letter to the Editor

There is growing evidence that oxidative stress plays a major role in Parkinson’s disease (PD) etiology [1, 2]. Importantly, uric acid has been shown in experimental studies to have an antioxidant effect on neurons [3, 4]. Recently, several observational studies have also evaluated associations between serum uric acid levels and PD risk and have consistently reported a lower risk of PD among individuals with the highest levels of serum uric acid [5, 6, 7, 8, 9, 10]. The most common metabolic disorder underlying hyper uricemia is gout. Thus, if hyperuricemia decreases the risk of PD, gout should also be negatively associated with PD risk. Two studies, to date, have evaluated the association between gout and PD risk and both reported an inverse association [11, 12], although the association was only observed among men in one of the two studies [11].

Using Danish population registers, we aimed to confirm the findings from these two previous observational studies. We investigated whether a...


Chronic Obstructive Pulmonary Disease Uric Acid Gout Serum Uric Acid Hyperuricemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by a grant from the National Institutes of Environmental Health Sciences, USA (Grant No. R01 ES013717). Partial funding was also provided by the National Institutes of Neurologic Diseases and Stroke, USA for the UCLA Udall Parkinson Disease Center of Excellence Grant No. P50 NS038367). The funding source had no role in the design or analysis of the study or in the decision to submit the manuscript for publication.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Eva Schernhammer
    • 1
    • 2
    • 3
    • 7
  • Jiaheng Qiu
    • 4
  • Lene Wermuth
    • 5
  • Christina Funch Lassen
    • 6
  • Soren Friis
    • 6
  • Beate Ritz
    • 4
  1. 1.Channing Division of Network Medicine, Department of MedicineHarvard Medical SchoolBostonUSA
  2. 2.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  3. 3.LBI-ACR and ACR-ITR VIEnna/CEADDPViennaAustria
  4. 4.Department of EpidemiologyUCLA School of Public HealthLos AngelesUSA
  5. 5.Department of NeurologyOdense University HospitalOdenseDenmark
  6. 6.Danish Cancer Society Research CenterDanish Cancer SocietyCopenhagenDenmark
  7. 7.Channing Division of Network MedicineBostonUSA

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