Familial effects on survival after myocardial infarction: a registry-based sib-pair study
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The chance of surviving an acute myocardial infarction (MI) has increased greatly but many persons still die as a consequence of MI. We assessed the familiality of suffering fatal MI using Swedish registry data. All 4,239 sib-pairs (n = 8,478) where both siblings had suffered an MI and who were born 1932 or later were identified by matching the Swedish National Patient-, Cause of Death and Multi-Generation registries. The Cox proportional hazards model was used to estimate the association between survival times between sibling who had, or not had, a sibling who died within 28 days of their first MI. The risk estimate was adjusted for year of infarction, age at infarction, sex and county for both siblings. The mortality rate was increased the first 28 days after infarction amongst patients who had a sibling who also died within 28 days of infarction (adjusted Hazard ratio (HR) [95 % confidence interval [95 % CI]: 1.44 [1.18–1.75]). These patients also have a worse long-term survival (adjusted HR [95 % CI]: 1.65 [1.24–2.21]). There appears to be familial effects that influence MI survival. This may have important implications for MI prevention strategies but further studies are required to determine if these effects are due to genetic or environmental factors.
KeywordsMyocardial Infarction Family-based study Mortality Registers Familiality
This study was supported by grants from Karolinska Institutet Foundations and Hans Loo Ostermans Foundation.
Conflicts of interest
The authors declare that they have no conflict of interest.
- 2.Open comparison and assessment 2009-Cardiac care. Swedish National Board of Health and Welfare, Stockholm, Sweden. 2010. http://www.socialstyrelsen.se/publikationer2010/2010-9-2 Accessed 1 June 2012.
- 15.Värdering av diagnoskvaliteten för akut hjärtinfarkt i patientregistret 1987 och 1995. Swedish National Board of Health and Welfare, Stockholm, Sweden. 2000. http://www.socialstyrelsen.se/publikationer2000/2000-0-100 Accessed 30 May 2012.
- 16.Multi-generation register 2010, a description of contents and quality. Statistics Sweden, Stockholm, Sweden. 2011. http://www.scb.se/statistik/_publikationer/BE9999_2011A01_BR_BE96BR1101.pdf. Accessed 1 June 2012.