Prevalence of type 2 diabetes in Germany in 2040: estimates from an epidemiological model
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To estimate the number of persons in the age-group 55–74 years with type 2 diabetes in Germany until 2040 and to analyze the impact of an intervention in a high risk group. A Markov model is used to generate forecasts by age and sex in each year using inputs of estimated diabetes prevalence, incidence and mortality based on actual national data. Projections about future demographics stem from the German Federal Office of Statistics. In a slightly modified model a state for persons with prediabetes is included to study the interplay of effect-size and participation quote on the number of persons with diabetes. The projected number of people with type 2 diabetes aged 55–74 years rises from 2.4 million in 2010 to 3.9 million in 2030. From 2030 on this number will decrease slightly to 3.3 million in 2040. If every second person aged 55–74 with prediabetes took part in a prevention program with the effect size of the Finnish Diabetes Prevention Program, 0.4 million cases could be prevented until 2030. To prevent 1.0 million cases in 2030, 90 % of all persons with prediabetes had to take part in an intervention that reduces the transition rate from prediabetes to diabetes by 55 %. Unless enormous efforts are spent into prevention programs, the number of persons with type 2 diabetes will increase tremendously in the next two decades.
KeywordsEpidemiology Type 2 diabetes Prediabetes Prediction Modelling Prevention
Impaired fasting glucose
Impaired glucose tolerance
- 95 % CI
95 % confidence interval
Cooperative Health Research in the Region of Augsburg
Conflict of interest
- 1.Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011;378(9785):31–40.PubMedCrossRefGoogle Scholar
- 2.Sicree R, Shaw J, Zimmet R. The global burden: diabetes and impaired glucose tolerance. Background material for the IDF Diabetes Atlas. http://www.idf.org/diabetesatlas/downloads/backgroundpapers. Accessed 27 July 2011.
- 3.US Census Bureau. US Population Projections. http://www.census.gov/population/www/projections/index.html. Accessed 27 July 2011.
- 4.Office for National Statistics. National Population Projections. http://www.statistics.gov.uk/StatBase/Product.asp?vlnk=8519. Accessed 27 July 2011.
- 5.Federal Statistical Office of Germany. 12. Population Projection [12. Koordinierte Bevölkerungsvorausberechnung]. http://www.destatis.de. Accessed 27 July 2011.
- 8.Schipf S, Werner A, Tamayo T, Holle R, Schunk M, Maier W, Meisinger C, Thorand B, Berger K, Mueller G, Moebus S, Bokhof B, Kluttig A, Greiser KH, Neuhauser H, Ellert U, Icks A, Rathmann W, Völzke H. Regional differences in the prevalence of known type 2 diabetes mellitus in 45–74 years old individuals: results from six population-based studies in Germany (DIAB-CORE Consortium). Diabet Med. 2012;. doi: 10.1111/j.1464-5491.2012.03578.x.Google Scholar
- 15.Keiding N, Hansen BE, Holst C. Nonparametric estimation of disease incidence from a cross-sectional sample of a stationary population. Lect Notes Biomath. 1990;86:36–45.Google Scholar