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Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case–control study

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Abstract

The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case–control study. The study population included 197 incident BC cases and 211 controls. The association between genetic polymorphisms, coffee drinking and BC risk was assessed by logistic regression taking into account age, education, tobacco smoking and occupational exposures to polycyclic aromatic hydrocarbons and aromatic amines. No association was found between the genetic polymorphisms investigated and BC risk according to coffee consumption apart of a significant increased BC risk among GSTP1 105-114 Val carriers heavy coffee drinkers (>3 cups/day) (OR 3.18, 95%CI 1.06–9.55). In conclusion our findings suggest a very limited role, if any, of genetic polymorphisms investigated in modulating the BC risk in coffee drinkers.

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Abbreviations

AA:

Aromatic amines

BC:

Bladder cancer

CI:

Confidence interval

GST:

Glutathione S-transferases

HWE:

Hardy–Weinberg equilibrium

NAT:

N-acetyltransferase

OR:

Odds ratio

PAH:

Polycyclic aromatic hydrocarbons

SULT1A1:

Sulfotransferase 1A1

XPD:

Xeroderma pigmentosum complementation group

XRCC:

X-ray repair cross-complementing

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Authors and Affiliations

  1. Department of Experimental and Applied Medicine, Institute of Hygiene, Epidemiology and Public Health, University of Brescia, Viale Europa 11, 25123, Brescia, Italy

    Loredana Covolo, Umberto Gelatti, Paolo Lodetti, Antonio Piccichè & Grazia Orizio

  2. Section of Occupational Health, University of Brescia, Brescia, Italy

    Donatella Placidi, Angela Carta, Antonio Scotto Di Carlo, Marcello Campagna, Cecilia Arici & Stefano Porru

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  1. Loredana Covolo
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  2. Donatella Placidi
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Correspondence to Loredana Covolo.

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Covolo, L., Placidi, D., Gelatti, U. et al. Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case–control study. Eur J Epidemiol 23, 355–362 (2008). https://doi.org/10.1007/s10654-008-9238-2

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  • DOI: https://doi.org/10.1007/s10654-008-9238-2

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