Skip to main content
SpringerLink
Log in

Nitrate in Community Water Supplies and Risk of Childhood Type 1 Diabetes in Sardinia, Italy

  • Letters to the Editor
  • Published:
European Journal of Epidemiology Aims and scope Submit manuscript

Abstract

We tested the hypothesis of an association between childhood type 1 diabetes (T1D) risk and nitrate concentration in drinking water in Sardinia, Italy, using Poisson regression analysis. Childhood T1D risk showed an inverse trend with increasing quartile of nitrate level in the total population and among men. A nitrate concentration in drinking water below 10 mg/l is unlikely to account for the spatial variation in childhood T1D incidence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. MP Longnecker JL. Daniels (2001) ArticleTitleEnvironmental contaminants as etiologic factors for diabetes Environ Health Perspect 109 IssueIDSuppl 6 871–876 Occurrence Handle11744505

    PubMed  Google Scholar 

  2. JN Kostraba EC Gay M Rewers FR. Hamman (1992) ArticleTitleNitrate levels in community drinking waters and risk of IDDM Diabetes Care 15 1505–1508 Occurrence Handle1:STN:280:ByyC3crns1U%3D Occurrence Handle1468277

    CAS  PubMed  Google Scholar 

  3. RC Parslow PA McKinney GR Law A Staines R Williams HJ. Bodansky (1997) ArticleTitleIncidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: An ecological analysis Diabetologia 40 550–556 Occurrence Handle10.1007/s001250050714 Occurrence Handle1:STN:280:ByiA3cjpvFM%3D Occurrence Handle9165223

    Article  CAS  PubMed  Google Scholar 

  4. E Moltchanova M Rytkönen A Kousa O Taskinen J Tuomilehto M. Karvonen (2004) ArticleTitleFor the Spat Study Group and the Finnish Childhood Diabetes Registry group. Zinc and nitrate in the ground water and the incidence of type 1 diabetes in Finland Diabetic Med 21 256–261 Occurrence Handle10.1111/j.1464-5491.2004.01125.x Occurrence Handle1:CAS:528:DC%2BD2cXislOnsbg%3D Occurrence Handle15008836

    Article  CAS  PubMed  Google Scholar 

  5. M Karvonen M Viik-Kajander E Moltchanova I Libman R LaPorte J. Tuomilehto (2000) ArticleTitleFor the Diabetes Mondiale (DiaMond) Project Group. Incidence of childhood type 1 diabetes worldwide Diabetes Care 23 1516–1526 Occurrence Handle1:STN:280:DC%2BD3cvmvVaqtA%3D%3D Occurrence Handle11023146

    CAS  PubMed  Google Scholar 

  6. A Casu M Carlini A Contu GF Bottazzo M. Songini (2000) ArticleTitleType 1 diabetes in Sardinia is not linked to nitrate levels in drinking water Diabetes Care 23 1043–1044 Occurrence Handle1:STN:280:DC%2BD3M%2FhtlGhsA%3D%3D Occurrence Handle10895879

    CAS  PubMed  Google Scholar 

  7. HX Zhao MD Mold EA Stenhouse SC Bird DE Wright AG Demaine BA. Millward (2001) ArticleTitleDrinking water composition and childhood-onset type 1 diabetes mellitus in Devon and Cornwall, England Diabetic Med 18 709–717 Occurrence Handle10.1046/j.1464-5491.2001.00554.x Occurrence Handle1:CAS:528:DC%2BD3MXnvVygs7g%3D Occurrence Handle11606168

    Article  CAS  PubMed  Google Scholar 

  8. JMS Maanen ParticleVan HJ Albering SGJ Breda ParticleVan DMJ Curfs AW Ambergen BHR Wolffenbuttel JCS Kleinjans HM. Reeser (1999) ArticleTitleNitrate in drinking water and risk of childhood diabetes in the Netherlands (letter) Diabetes Care 22 1750 Occurrence Handle10526751

    PubMed  Google Scholar 

  9. S Muntoni (1994) ArticleTitleIl diabete insulino-dipendente in Sardegna nel periodo 1989–1992 Epidemiologia Sardegna 2/4 67–76

    Google Scholar 

  10. Breslow NE, Day NE. Statistical Methods in Cancer Research. Vol. 1–The Analysis of Case–Control Studies. Lyon, France: International Agency for Research on Cancer; IARC Scientific Publications no 32, 1980.

  11. SM Virtanen L Jaakkola L Rasanen K Ylonen R Lounamaa HK Åkerblom J. Tuomilehto (1994) ArticleTitleNitrate and nitrite intake and the risk for type 1 diabetes in Finnish children Diabetic Med 11 656–662 Occurrence Handle1:STN:280:ByqD2cvgsVY%3D Occurrence Handle7955990

    CAS  PubMed  Google Scholar 

  12. E Schober B Rami T Waldhoer (2003) ArticleTitleSmall area variation in childhood diabetes mellitus in Austria: Links to population density, 1989–1999 J Clin Epidemiol 56 269–273 Occurrence Handle10.1016/S0895-4356(02)00607-8 Occurrence Handle12725882

    Article  PubMed  Google Scholar 

  13. GG Dahlquist LG Blom LA Persson AI Sandstrom SG. Wall (1990) ArticleTitleDietary factors and the risk of developing insulin dependent diabetes in childhood Br Med J 300 1302–1306 Occurrence Handle1:STN:280:By%2BA3MrkslM%3D

    CAS  Google Scholar 

  14. MH Ward TM deKok P Levallois J Brender G Gulis BT Nolan J VenDerslice (2005) ArticleTitleInternational Society for Environmental Epidemiology. Workgroup report: Drinking-water nitrate and health – Recent findings and research needs Environ Health Perspect 113 1607–1614 Occurrence Handle1:CAS:528:DC%2BD2MXht12isbjE Occurrence Handle16263519

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Cagliari, Italy

    Sandro Muntoni

  2. Center for Metabolic Diseases and Atherosclerosis, The ME.DI.CO. Association, Cagliari, Italy

    Sandro Muntoni & Sergio Muntoni

  3. Department of Public Health, Occupational Health Section, University of Cagliari, via San Giorgio 12, 09124, Cagliari, Italy

    Pierluigi Cocco & Gabriella Aru

Authors
  1. Sandro Muntoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pierluigi Cocco
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sergio Muntoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gabriella Aru
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pierluigi Cocco.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Muntoni, S., Cocco, P., Muntoni, S. et al. Nitrate in Community Water Supplies and Risk of Childhood Type 1 Diabetes in Sardinia, Italy. Eur J Epidemiol 21, 245–247 (2006). https://doi.org/10.1007/s10654-006-0014-x

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10654-006-0014-x

Keywords

Search

Navigation