Abstract
Study objective: To asses the association between alcohol consumption and the risk of colorectal cancer (CRC) in the Chinese population. Design: A population-based prospective cohort study was initiated from the colorectal cancer screening population in Jiashan County in 1989–1990. The drinking habits of individuals were investigated with demographic information. Setting: A cohort study was followed-up from 1st May 1990 to 1st January 2001 and censored at the date of diagnosis of CRC, at death from any causes, or at 1st January 2001, whichever came first, and the person-time was computed. Participants: Two hundred and forty two CRC patients were diagnosed during the study period and 64,100 individuals finished the follow-up. Results: The distribution of sex, smoking status, occupation, education level and marital status were all significantly different among different drinking habits at baseline. When the above factors were adjusted, no significant association was observed between alcohol consumption and the risk of CRC. Exclusion of individuals diagnosed cancer less than 1 year after the examination date did not alter the strength of an alcohol–CRC relationship. Further analysis in sex strata also did not show a significant relationship. Conclusions: Alcohol drinking may not be associated with a higher risk of CRC in the Chinese population.
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References
JT Efird GD Friedman L Habel et al. (2002) ArticleTitleRisk of subsequent cancer following invasive or in situ squamous cell skin cancer. Ann Epidemiol 12 469–475
F Von-Weizsacker HP Allgaier HE Blum (2002) ArticleTitlePravention des hepatozellularen Karzinoms (Prevention of hepatocellular carcinoma). Schweiz Rundsch Med Prax 91 1393–1395
A.J Tuyns (2001) ArticleTitleAlchol et cancer (Alcohol and cancer). Pathol Biol (Paris) 49 759–763
International Agency for Research on Cancer. Alcohol drinking. IARC Working Group, Lyon, 13-20 October 1987. IARC Monogr Eval Carcinog Risks Hum 1988; 44: 1-378.
World Health Organization (WHO). The World Health Report. Geneva (Switzerland): WHO; 1997.
Waterhouse J, Muir C, Shanmugaratnam K, et al. Cancer incidence in five continents. Volume IV. IARC Sci Publ 1982; (42): 1–807.
LD Li KQ Rao (2000) ArticleTitleAn analysis of cancer incidence and death register data in 1988–1992, in 11 counties, China. Bull Chinese Cancer 9 435–447
K Chen J Cai XY Liu et al. (2003) ArticleTitleNested case–control study on the risk factors of colorectal cancer. World J Gastroenterol 9 99–103
WX Zhu JJ Lin (1988) ArticleTitleReverse passive hemagglutination for detection of fecal occult blood. Chin Med J 10l 519–522
XY Ma KY Yao (2002) ArticleTitleAn investigate of report quality and fail to report rate of cancer register system in Jiaoshan county. Zhejiang J Prevent Med 14(5) 19–20
Stocks P. Cancer incidence in North Wales and Liverpool region in relation to habits and environment. Br Emp Cancer Campaign 35th Annu Rep 1957; 1: 127.
JD Potter (1999) ArticleTitleCRC: Molecules and populations. J Natl Cancer Ins 91 916–932
MP Longnecker MJ Orza ME Adams et al. (1990) ArticleTitleA meta-analysis of alcoholic beverage consumption in relation to risk of colorectal cancer. Cancer Causes Control 1 59–68
V Bagnardi M Blangiardo C La Vecchhia et al. (2001) ArticleTitleA meta-analysis of alcohol drinking and cancer risk. Br J Cancer 85 1700–1705
Cho EY, Smith-Warner AS, Ritz J, et al. Alcohol intake and colorectal cancer: A polled analysis of 8 cohort studies. Ann Intern Med 140: 603–613.
XY Liu L Zhou K Chen (1994) ArticleTitleA case–control study of risk of colorectal cancer in Jiashan County. Chin J Prevention Control of Chron Non-Communicable Dis 2 122–124
XH Wang TH Lei XY Ma (2001) ArticleTitleA case–control study on risk of colon cancer. Chin J Cancer 23 480–482
K Chen JL Qiu Y Zhang (2002) ArticleTitleA meta-analysis on the risk factors of colorectal cancer. J Zhejiang Univ (Med Sci) 31 254–258
World Health Organization (WHO). Cancer: Diet and physical activity’s impact. http//www.who.int.
EL Wynder MH Mushinski JC Spivak (1977) ArticleTitleTobacco and alcohol consumption in relation to the development of multiple primary cancers. Cancer 40 (Suppl) 1872–1878
LD Li FZ Lu SW Zhang et al. (1997) ArticleTitleAn analysis of 20-year change trend and recent forecast of Chinese malignant cancers. Chin J Oncol 19 3–9
RS Houlston IPM Tomlinson (2001) ArticleTitlePolymorphisms and colorectal tumor risk. Gastroenterology 21 281–231
J Ma MJ Stampfer E Giovannucci et al. (1997) ArticleTitleMethylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of CRC. Cancer Res 57 1098–1102
Chen J, Giovannucci EL, Hunter DJ. MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: An example of gene-environment interactions in colorectal tumorigenesis. J Nutr 1999; 129 (Suppl. 2S): 560S–564S.
T Marugam E Tsuji H Inoue et al. (2000) ArticleTitleMethylenetetrahydrofolate reducatase polymorphism and risk of colorectal adenomas. Cancer Lett 151 181–186
A Flood L Caprario N Chaterjee et al. (2002) ArticleTitleFolate, methionine, alcohol, and colorectal cancer in a prospective study of women in the United States. Cancer Causes Control 13 551–561
E Giovannucci EB Rimm A Ascherio et al. (1995) ArticleTitleAlcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 87 265–273
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Chen, K., Jiang, Q., Ma, X. et al. Alcohol drinking and colorectal cancer: A population-based prospective cohort study in China. Eur J Epidemiol 20, 149–154 (2005). https://doi.org/10.1007/s10654-004-2953-4
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DOI: https://doi.org/10.1007/s10654-004-2953-4