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A follow-up study of the development of skin lesions associated with arsenic exposure duration

  • Binggan Wei
  • Jiangping Yu
  • Chang Kong
  • Hairong Li
  • Linsheng Yang
  • Yajuan Xia
  • Kegong Wu
Original Paper

Abstract

Little information about the development of skin lesions in relation to arsenic exposure duration is available. Therefore, skin lesions in a cohort from the Bameng region of China were diagnosed in 2012 and 2017. The results indicated that the prevalence of hyperkeratosis, pigmentation and depigmentation in 2017 was 64.67, 6.67 and 12.67%. There were 42 and 34% of male subjects and female subjects suffered from skin lesions in 2012. Their morbidity rates were 10.43 and 8.98 per 1000 person-years. In 2017, the values were significantly increased. The prevalence and morbidity rate of skin lesions were positively correlated with age and arsenic levels in drinking water. Males had higher prevalence of skin lesions compared with female. However, the ≤ 40 years female group had higher prevalence of skin lesions. In addition, the increased rate of skin lesions prevalence was negatively correlated with arsenic levels in drinking water. The odds ratios (ORs) showed that the risks of skin lesions were positively associated with the proportion of inorganic arsenic (%iAs) and monomethylarsonic acid (%MMA) in urine, and negatively correlated with arsenic methylation capacity in both 2012 and 2017. It can be concluded that females immigrated from other areas were more susceptible to developing skin lesions. A certain cumulative arsenic exposure dose, which may be existing, significantly increased the prevalence of skin lesions. Longer arsenic exposure duration might elevate the toxicity of iAs to skin lesions and reduce the positive effects of arsenic methylation capacity on skin lesions.

Keywords

Arsenic Drinking water Skin lesions Development Exposure duration 

Notes

Acknowledgements

The work described in this paper was financially supported by the National Natural Science Foundation of China (Grant No. 41601559) and the State Key Program of National Natural Science Foundation of China (Grant No. 41230749).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

10653_2018_136_MOESM1_ESM.pdf (212 kb)
Supplementary material 1 (PDF 212 kb)

References

  1. Ahsan, H., Chen, Y., Kibriya, M. G., Slavkovich, V., Jasmine, F., Gamble, M. V., et al. (2007). Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Cancer Epidemiology, Biomarkers and Prevention, 16, 1270–1278.CrossRefGoogle Scholar
  2. Bhattacharjee, P., Banerjee, M., & Giri, A. K. (2013). Role of genomic in stability in arsenic induced carcinogenicity: A review. Environment International, 53, 29–40.CrossRefGoogle Scholar
  3. Bräuner, E., Nordsborg, R. B., Andersen, Z. J., Tjonneland, A., Loft, S., & Raaschou-Nielsen, O. (2014). Long-term exposure to low-level arsenic in drinking water and diabetes incidence: A prospective study of the diet, cancer and health cohort. Environmental Health Perspectives, 122, 1059–1065.CrossRefGoogle Scholar
  4. Guo, X., Fujino, Y., Kaneko, S., Wu, K., Xia, Y., & Yoshimura, T. (2001). Arsenic contamination of groundwater and prevalence of arsenical dermatosis in the Hetao plain area, Inner Mongolia, China. Molecular and Cellular Biochemistry, 222, 137–140.CrossRefGoogle Scholar
  5. IARC. (2004) Arsenic in drinking water. IARC monograph evaluation of carcinogenic risks to humans, Vol. 84, pp. 39–267.Google Scholar
  6. Kapaj, S., Peterson, H., Liber, K., & Bhattacharya, P. (2006). Human health effects from chronic arsenic poisoning—A review. Journal of Environmental Science and Health, Part A Environmental Science, 41, 2399–2428.CrossRefGoogle Scholar
  7. Karagas, M. R., Gossai, A., Pierce, B., & Ahsan, H. (2015). Drinking water arsenic contamination, skin lesions, and malignancies: A systematic review of the global evidence. Current Environmental Health Reports, 2, 52–68.CrossRefGoogle Scholar
  8. Kile, M. L., Hoffman, E., Rodrigues, E. G., Breton, C. V., Quamruzzaman, Q., Rahman, M., et al. (2011). A pathway-based analysis of urinary arsenic metabolites and skin lesions. American Journal of Epidemiology, 173, 778–786.CrossRefGoogle Scholar
  9. Li, L., Ekström, E. C., Goessler, W., Lönnerdal, B., Nermell, B., Yunus, M., et al. (2008). Nutritional status has marginal influence on the metabolism of inorganic arsenic in pregnant Bangladeshi women. Environmental Health Perspectives, 116, 315–321.CrossRefGoogle Scholar
  10. Li, X., Li, B., Xi, S., Zheng, Q., Wang, D., & Sun, G. (2013). Association of urinary monomethylated arsenic concentration and risk of hypertension: A cross-sectional study from arsenic contaminated areas in northwestern China. Environmental Health, 12, 37–46.CrossRefGoogle Scholar
  11. Lindberg, A. L., Ekström, E. C., Nermell, B., Rahman, M., Lönnerdal, B., Persson, L. A., et al. (2008a). Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh. Environmental Research, 106, 110–120.CrossRefGoogle Scholar
  12. Lindberg, A. L., Rahman, M., Persson, L. Å., & Vahter, M. (2008b). The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure. Toxicology and Applied Pharmacology, 230, 9–16.CrossRefGoogle Scholar
  13. Mazumder, D. N. G., Haque, R., Ghosh, N., De, B. K., Santra, A., Chakraborty, D., et al. (1998). Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal, India. International Journal of Epidemiology, 27, 871–877.CrossRefGoogle Scholar
  14. Melak, D., Ferreccio, C., Kalman, D., Parra, R., Acevedo, J., Perez, L., et al. (2014). Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile. Toxicology and Applied Pharmacology, 274, 225–231.CrossRefGoogle Scholar
  15. Mosaferi, M., Yunesian, M., Dastgiri, S., Mesdaghinia, A., & Esmailnasab, N. (2008). Prevalence of skin lesions and exposure to arsenic in drinking water in Iran. Science of the Total Environment, 390, 69–76.CrossRefGoogle Scholar
  16. Pan, W. C., Seow, W. J., Kile, M. L., Hoffman, E. B., Quamruzzman, Q., Rahman, M., et al. (2013). Association of low to moderate levels of arsenic exposure with risk of type 2 diabetes in Bangladesh. American Journal of Epidemiology, 178, 1563–1570.CrossRefGoogle Scholar
  17. Pierce, B. L., Tong, L., Argos, M., Gao, J., Farzana, J., Roy, S., et al. (2013). Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction. International Journal of Epidemiology, 42, 1862–1872.CrossRefGoogle Scholar
  18. Rahman, M. M., Chowdhury, U. K., Mukherjee, S. C., Mondal, B. K., Paul, K., Lodh, D., et al. (2001). Chronic arsenic toxicity in Bangladesh and West Bengal, India—A review and commentary. Journal of Toxicology - Clinical Toxicology, 39, 683–700.CrossRefGoogle Scholar
  19. Rahman, M., Vahter, M., Sohel, N., Yunus, M., Wahed, M. A., Streatfield, P. K., et al. (2006a). Arsenic exposure and age- and sexspecific risk for skin lesions: A population-based case-referent study in Bangladesh. Environmental Health Perspectives, 114, 1847–1852.CrossRefGoogle Scholar
  20. Rahman, M., Vahter, M., Wahed, M. A., Sohel, N., Yunus, M., Streatfield, P. K., et al. (2006b). Prevalence of arsenic exposure and skin lesions. A population based survey in Matlab, Bangladesh. Journal of Epidemiology and Community Health, 60, 242–248.CrossRefGoogle Scholar
  21. Ren, X., McHale, C. M., Skibola, C. F., Smith, A. H., Smith, M. T., et al. (2010). An emerging role for epigenetic dysregulationin arsenic toxicity. Environmental Health Perspectives, 119, 11–19.CrossRefGoogle Scholar
  22. Rodríguez-Lado, L., Sun, G., Berg, M., Zhang, Q., Xue, H., Zheng, Q., et al. (2013). Groundwater arsenic contamination throughout China. Science, 341, 866–868.CrossRefGoogle Scholar
  23. Shen, H., Niu, Q., Xu, M., Rui, D., Xu, S., Feng, G., et al. (2016). Factors affecting arsenic methylation in arsenic-exposed humans: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 13, 205–222.CrossRefGoogle Scholar
  24. Somé, I. T., Sakira, A. K., Ouédraogom, M., Ouédraogo, T. Z., Traore, A., Sondo, B., et al. (2012). Arsenic levels in tube-wells water, food, residents’ urine and the prevalence of skin lesions in Yatenga province, Burkina Faso. Interdisciplinary Toxicology, 5, 38–41.CrossRefGoogle Scholar
  25. Sun, G., Xu, Y., Li, X., Jin, Y., Li, B., & Sun, X. (2007). Urinary arsenic metabolites in children and adults exposed to arsenic in drinking water in Inner Mongolia, China. Environmental Health Perspectives, 115, 648–652.CrossRefGoogle Scholar
  26. Torres-Sánchez, L., López-Carrillo, L., Rosado, J. L., Rodriguez, V. M., Vera-aguilar, E., Kordas, K., et al. (2016). Sex differences in the reduction of arsenic methylation capacity as a function of urinary total and inorganic arsenic in Mexican children. Environmental Research, 151, 38–43.CrossRefGoogle Scholar
  27. Tseng, C. H. (2007). Arsenic methylation, urinary arsenic metabolites and human diseases: Current perspective. Journal of Environmental Science and Health, Part C, 25, 1–22.CrossRefGoogle Scholar
  28. Tseng, C. H. (2009). A review on environmental factors regulating arsenic methylation in humans. Toxicology and Applied Pharmacology, 235, 338–350.CrossRefGoogle Scholar
  29. Valenzuela, O. L., Drobná, Z., Hernández-Castellanos, E., Sánchez-Penal, L. C., García-Vargas, G. G., Borja-Aburto, V. H., et al. (2009). Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions. Toxicology and Applied Pharmacology, 239, 200–207.CrossRefGoogle Scholar
  30. Wei, B., Yu, J., Li, H., Yang, L., Xia, Y., Wu, K., et al. (2016). Arsenic metabolites and methylation capacity among individuals living in a rural area with endemic arseniasis in Inner Mongolia, China. Biological Trace Element Research, 170, 300–308.CrossRefGoogle Scholar
  31. Wei, B., Yu, J., Yang, L., Li, H., Chai, Y., Xia, Y., et al. (2017). Arsenic methylation and skin lesions in migrant and native adult women with chronic exposure to arsenic from drinking groundwater. Environmental Geochemistry and Health, 39, 89–98.CrossRefGoogle Scholar
  32. Wen, J., Wen, W., Li, L., & Liu, H. (2012). Methylation capacity of arsenic and skin lesions in smelter plant workers. Environmental Toxicology and Pharmacology, 34, 624–630.CrossRefGoogle Scholar
  33. World Health Organization (WHO). (2001). United Nations synthesis report on arsenic in drinking water. Geneva: WHO.Google Scholar
  34. Yang, L., Chai, Y., Yu, J., Wei, B., Xia, Y., Wu, K., et al. (2017). Associations of arsenic metabolites, methylation capacity, and skin lesions caused by chronic exposure to high arsenic in tube well water. Environmental Toxicology, 32, 28–36.CrossRefGoogle Scholar
  35. Yang, L., Wang, W., Hou, S., Williams, W. P., & Peterson, P. J. (2002). Arsenism clinical stages and their relation with hair arsenic concentration of residents of Bayinmaodao district, Inner Mongolia, China. Environmental Geochemistry and Health, 24, 337–348.CrossRefGoogle Scholar
  36. Zhang, Q., Li, Y., Liu, J., Wang, D., Zheng, Q., & Sun, G. (2014). Differences of urinary arsenic metabolites and methylation capacity between individuals with and without skin lesions in Inner Mongolia, Northern China. International Journal of Environmental Research and Public Health, 11, 7319–7332.CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingPeople’s Republic of China
  2. 2.Collage of Resources and EnvironmentUniversity of Chinese Academy of SciencesBeijingPeople’s Republic of China
  3. 3.Inner Mongolia Center for Comprehensive Disease Control and PreventionHohhotPeople’s Republic of China

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