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Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements

  • Marina M. S. Cabral Pinto
  • A. Paula Marinho-Reis
  • Agostinho Almeida
  • Carlos M. Ordens
  • Maria M. V. G. Silva
  • Sandra Freitas
  • Mário R. Simões
  • Paula I. Moreira
  • Pedro A. Dinis
  • M. Luísa Diniz
  • Eduardo A. Ferreira da Silva
  • M. Teresa Condesso de Melo
Original Paper

Abstract

New lines of evidence suggest that less than 10% of neurodegenerative diseases have a strict genetic aetiology and other factors may be prevalent. Environmental exposures to potentially toxic elements appear to be a risk factor for Parkinson’s, Alzheimer’s and sclerosis diseases. This study proposes a multidisciplinary approach combining neurosciences, psychology and environmental sciences while integrating socio-economic, neuropsychological, environmental and health data. We present the preliminary results of a neuropsychological assessment carried out in elderly residents of the industrial city of Estarreja. A battery of cognitive tests and a personal questionnaire were administered to the participants. Multivariate analysis and multiple linear regression analysis were used to identify potential relationships between the cognitive status of the participants and environmental exposure to potentially toxic elements. The results suggest a relationship between urinary PTEs levels and the incidence of cognitive disorders. They also point towards water consumption habits and profession as relevant factors of exposure. Linear regression models show that aluminium (R 2 = 38%), cadmium (R 2 = 11%) and zinc (R 2 = 6%) are good predictors of the scores of the Mini-Mental State Examination cognitive test. Median contents (µg/l) in groundwater are above admissible levels for drinking water for aluminium (371), iron (860), manganese (250), and zinc (305). While the World Health Organization does not provide health-based reference values for aluminium, results obtained from this study suggest that it may have an important role in the cognitive status of the elderly. Urine proved to be a suitable biomarker of exposure both to elements with low and high excretion rates.

Keywords

Neurodegenerative diseases Environmental exposure Potentially toxic elements Urine Groundwater 

Notes

Acknowledgements

Funding for this research was provided by the Labex DRIIHM, Réseau des Observatoires Hommes-Millieux–Centre National de la Recherche Scientifique (ROHM–CNRS) and OHM.I-Estarreja and by the Foundation for Science and the Technology (SFRH/BPD/71030/2010 and the Projects UI/D/GEO/04035/2013 and UID/MAR/04292/2013). We thank the participants for taking part in this research and the local private institutions of social solidarity for the collaboration (Santa Casa Misericórdia de Estarreja, Associação Humanitária de Salreu, Centro Paroquial Social São Tomé de Canelas, Centro Paroquial Social Avanca, Fundação Cónego Filipe Figueiredo Beduíno, Centro Paroquial de Pardilhó). The authors are grateful to Eugénio Soares from the Central Laboratory of University of Aveiro. The manuscript benefited from careful and constructive reviews by Shweta Modgil and two anonymous reviewers.

Supplementary material

10653_2017_9928_MOESM1_ESM.xlsx (14 kb)
Supplementary material 1 (XLSX 14 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Marina M. S. Cabral Pinto
    • 1
    • 2
    • 3
  • A. Paula Marinho-Reis
    • 1
  • Agostinho Almeida
    • 4
  • Carlos M. Ordens
    • 5
  • Maria M. V. G. Silva
    • 3
    • 6
  • Sandra Freitas
    • 2
    • 7
  • Mário R. Simões
    • 7
    • 8
  • Paula I. Moreira
    • 2
    • 9
  • Pedro A. Dinis
    • 3
    • 10
  • M. Luísa Diniz
    • 1
  • Eduardo A. Ferreira da Silva
    • 1
  • M. Teresa Condesso de Melo
    • 11
  1. 1.Department of GeosciencesGeobiotec Research Centre, University of AveiroAveiroPortugal
  2. 2.CNC-Center for Neuroscience and Cell Biology, Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  3. 3.Department of Earth SciencesUniversity of CoimbraCoimbraPortugal
  4. 4.LAQV/REQUIMTE, Department of Chemical Sciences, Laboratory of Applied Chemistry, Faculty of PharmacyPorto UniversityPortoPortugal
  5. 5.University College London AustraliaAdelaideAustralia
  6. 6.CEMUCUniversity of CoimbraCoimbraPortugal
  7. 7.Centro de Investigação do Núcleo de Estudos e Intervenção Cognitivo Comportamental (CINEICC)Universidade de CoimbraCoimbraPortugal
  8. 8.Faculdade de Psicologia e de Ciências da Educação da Universidade de Coimbra (FPCE-UC)CoimbraPortugal
  9. 9.Laboratory of Physiology, Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  10. 10.MARE - Marine and Environmental Sciences CentreUniversity of CoimbraCoimbraPortugal
  11. 11.CEris, DECivil, Instituto Superior TécnicoUniversidade de LisboaLisbonPortugal

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